The KCNMA1 Polyclonal Antibody (CAB15283) is specifically designed for researchers studying the KCNMA1 protein, also known as the Slo1 potassium channel subunit. This antibody, raised in rabbits, is highly reactive with human samples and is validated for use in Western blot applications. By binding to the KCNMA1 protein, this antibody enables accurate detection and analysis in a variety of cell types.KCNMA1 plays a crucial role in regulating calcium-activated potassium channels, which are involved in various physiological processes such as smooth muscle contraction, neuronal excitability, and cell volume regulation.
Dysregulation of KCNMA1 has been implicated in conditions such as epilepsy, hypertension, and erectile dysfunction, making it a promising target for research in neurology, cardiology, and urology.By using the KCNMA1 Polyclonal Antibody, researchers can gain insight into the function and expression of KCNMA1 in different tissues and conditions, ultimately advancing our understanding of the role of potassium channels in health and disease. This antibody is a valuable tool for studies focused on ion channel function, drug development, and therapeutic interventions in various medical fields.
Product Name:
KCNMA1 Rabbit Polyclonal Antibody
SKU:
CAB15283
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 850-950 of human KCNMA1 (NP_001258447.1).
This gene encodes the alpha subunit of calcium-activated BK channel. The encoded protein is involved in several physiological processes including smooth muscle contraction, neurotransmitter release and neuronal excitability. Mutations in this gene are associated with a spectrum of neurological disorders including Paroxysmal Nonkinesigenic Dyskinesia 3, Idiopathic Generalized Epilepsy 16 and Liang-Wang syndrome.
Purification Method:
Affinity purification
Gene ID:
3778
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from Rat brain, using KCNMA1 Rabbit pAb (CAB15283) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 90s.
