The KCNK9 Polyclonal Antibody (CAB12583) is a valuable tool for researchers studying the KCNK9 gene, which encodes a potassium channel protein involved in the regulation of membrane potential and cell excitability. This antibody, produced in rabbits, exhibits high specificity for human samples and is validated for use in Western blot applications.By targeting the KCNK9 protein, this antibody enables the detection and analysis of KCNK9 expression in various cell types, making it a versatile tool for studies in the fields of neuroscience, cardiology, and ion channel research.
KCNK9 plays a crucial role in the maintenance of cellular electrical activity and has been implicated in various diseases, including cardiac arrhythmias and epilepsy.Understanding the function of KCNK9 and its impact on cell physiology is essential for the development of potential therapeutics targeting ion channel dysfunction. With the use of the KCNK9 Polyclonal Antibody, researchers can further explore the role of this potassium channel protein in health and disease.
Product Name:
KCNK9 Rabbit Polyclonal Antibody
SKU:
CAB12583
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 265-374 of human KCNK9 (NP_001269463.1).
SH-SY5Y,Mouse brain,Mouse large intestine,Mouse pancreas
Conjugate:
Unconjugated
Cellular Localization:
Cell membrane, Multi-pass membrane protein.
Calculated MW:
42kDa
Observed MW:
42kDa
This gene encodes a protein that contains multiple transmembrane regions and two pore-forming P domains and functions as a pH-dependent potassium channel. Amplification and overexpression of this gene have been observed in several types of human carcinomas. This gene is imprinted in the brain, with preferential expression from the maternal allele. A mutation in this gene was associated with Birk-Barel dysmorphism syndrome. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
51305
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using KCNK9 antibody (CAB12583) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
