The KCNK7 Polyclonal Antibody (PACO02293) is a valuable tool for researchers studying KCNK7, a member of the potassium channel subfamily K, responsible for regulating membrane potential and ion transport. The antibody, raised in rabbits, exhibits high reactivity with human samples and is validated for use in various applications, including Western blotting. By binding to the KCNK7 protein, this antibody enables the detection and analysis of KCNK7 expression in different cell types, making it a versatile option for studies in physiology and neurobiology.
KCNK7 is known to play a crucial role in neuronal excitability and synaptic transmission, making it a promising target for research related to neurological disorders and conditions such as epilepsy and pain. Additionally, KCNK7 may also be involved in other physiological processes, highlighting its importance as a potential therapeutic target. Understanding the function and regulation of KCNK7 is essential for developing novel treatment approaches that target ion channel function in various disease states.
Antibody Name:
KCNK7 Antibody
Antibody SKU:
PACO02293
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
WB:1:500-1:2000
Species Reactivity:
Human
Immunogen:
synthesized peptide derived from the C-terminal region of human TWIK-3.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
KCNK7; Potassium channel subfamily K member 7
UniProt Protein Function:
KCNK7: Probable potassium channel subunit. No channel activity observed in vitro as protein remains in the endoplasmic reticulum. May need to associate with an as yet unknown partner in order to reach the plasma membrane. Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, multi-pass; Membrane protein, integralChromosomal Location of Human Ortholog: 11q13Cellular Component: integral to membrane; plasma membraneMolecular Function: potassium channel activity; voltage-gated ion channel activityBiological Process: synaptic transmission; potassium ion transport
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the superfamily of potassium channel proteins containing two pore-forming P domains. The product of this gene has not been shown to be a functional channel; however, it may require other non-pore-forming proteins for activity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
