The KCNK5 Polyclonal Antibody (PAC010066) is a valuable tool for researchers studying the KCNK5 gene, which encodes a member of the potassium channel subfamily K. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding to the KCNK5 protein, this antibody allows for the detection and analysis of KCNK5 expression in various cell types, making it ideal for research in physiology, neuroscience, and cardiovascular biology.KCNK5 plays a crucial role in regulating the flow of potassium ions across cell membranes, impacting membrane potential and cell excitability.
Dysregulation of KCNK5 has been implicated in various physiological processes, including neuronal signaling, cardiac function, and smooth muscle contraction. Understanding the function of KCNK5 is essential for uncovering its potential role in diseases such as epilepsy, arrhythmias, and hypertension, making this antibody a valuable tool for researchers exploring these areas of study.
potassium channel, subfamily K, member 5;KCNK5;FLJ11035;K2p5.1;TASK-2;TASK2 ;
UniProt Protein Function:
pH-dependent, voltage insensitive, outwardly rectifying potassium channel. Outward rectification is lost at high external K+ concentrations.
UniProt Protein Details:
NCBI Summary:
This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The message for this gene is mainly expressed in the cortical distal tubules and collecting ducts of the kidney. The protein is highly sensitive to external pH and this, in combination with its expression pattern, suggests it may play an important role in renal potassium transport. [provided by RefSeq, Jul 2008]
