The KCNK3 Polyclonal Antibody (PAC020658) is a vital tool for research involving KCNK3, a potassium channel protein associated with various physiological functions, including regulation of cell membrane potential and ion transport. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for Western blot applications. By specifically binding to the KCNK3 protein, this antibody enables precise detection and analysis in a variety of cell types, making it ideal for studies in cardiology, neurology, and pulmonary research.KCNK3, also known as THIK-2, is a member of the two-pore domain potassium channel family and plays a crucial role in maintaining cellular excitability and regulating membrane potential in various tissues, including the heart and lungs.
Dysregulation of KCNK3 has been implicated in cardiac arrhythmias, pulmonary hypertension, and neurological disorders, highlighting its importance as a potential therapeutic target. Investigating the function of KCNK3 is essential for advancing our understanding of these conditions and developing targeted treatments to improve patient outcomes.
Gel: 8%SDS-PAGE, Lysate: 40 µg, Lane: Mouse heart tissue, Primary antibody: PACO20658(KCNK3 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds.
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO20658(KCNK3 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
This gene encodes a member of the superfamily of potassium channel proteins that contain two pore-forming P domains. The encoded protein is an outwardly rectifying channel that is sensitive to changes in extracellular pH and is inhibited by extracellular acid, fication. Also referred to as an acid, sensitive potassium channel, it is activated by the anesthetics halothane and isoflurane. Although three transcripts are detected in northern blots, there is currently no sequence available to confirm transcript variants for this gene.
Synonyms:
potassium channel, two pore domain subfamily K, member 3
UniProt Protein Function:
KCNK3: pH-dependent, voltage-insensitive, background potassium channel protein. Rectification direction results from potassium ion concentration on either side of the membrane. Acts as an outward rectifier when external potassium concentration is low. When external potassium concentration is high, current is inward. Widespread expression in adult. Strongest expression in pancreas and placenta. Lower expression in brain, lung, prostate, heart, kidney, uterus, small intestine and colon. Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.Protein type: Membrane protein, multi-pass; Membrane protein, integral; Channel, potassiumCellular Component: cytosol; integral to membrane; integral to plasma membrane; membrane; plasma membraneMolecular Function: ion channel activity; open rectifier potassium channel activity; potassium channel activity; potassium ion leak channel activity; protein C-terminus binding; protein heterodimerization activity; protein homodimerization activityBiological Process: ion transport; potassium ion transport; reduction of cytosolic calcium ion concentration; response to drug; stabilization of membrane potential; transport
