The KCNK17 Polyclonal Antibody (PAC016577) is a valuable tool for researchers studying the KCNK17 protein, a member of the two-pore domain potassium channel family that is involved in potassium ion transport across cell membranes. This antibody, raised in rabbits, is highly specific to human samples and has been validated for use in Western blot applications.KCNK17 plays a crucial role in the regulation of membrane potential and cell excitability, making it a key player in physiological processes such as neuronal signaling, muscle contraction, and hormone secretion. Dysregulation of KCNK17 has been associated with various diseases, including epilepsy, cardiac arrhythmias, and hypertension, making it an important target for drug development and therapeutic interventions.
By using the KCNK17 Polyclonal Antibody, researchers can gain insights into the expression and function of KCNK17 in different cell types and tissues, paving the way for further investigations into its role in health and disease. This antibody is an essential tool for studies in neuroscience, cardiology, and endocrinology, providing valuable information for the development of novel treatments and therapies.
The image on the left is immunohistochemistry of paraffin-embedded Human tonsil tissue using PACO16577(KCNK17 Antibody) at dilution 1/60, on the right is treated with fusion protein. (Original magnification: x200).
Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: LO2 cells, Primary antibody: PACO16577(KCNK17 Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds.
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO16577(KCNK17 Antibody) at dilution 1/60, on the right is treated with fusion protein. (Original magnification: x200).
Background:
The protein encoded by this gene belongs to the family of potassium channel proteins containing two pore-forming P domains. This channel is an open rectifier which primarily passes outward current under physiological K+ concentrations. This gene is activated at alkaline pH. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Synonyms:
potassium channel, subfamily K, member 17
UniProt Protein Function:
KCNK17: Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K(+) currents. Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.Protein type: Membrane protein, integral; Membrane protein, multi-passChromosomal Location of Human Ortholog: 6p21.2Cellular Component: integral component of plasma membrane; plasma membraneMolecular Function: potassium channel activity; potassium ion leak channel activity; voltage-gated ion channel activityBiological Process: potassium ion transport; stabilization of membrane potential
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene belongs to the family of potassium channel proteins containing two pore-forming P domains. This channel is an open rectifier which primarily passes outward current under physiological K+ concentrations. This gene is activated at alkaline pH. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]
