The KCNK17 Polyclonal Antibody (PACO05656) is a valuable tool for researchers studying the KCNK17 gene, which encodes a member of the K2P family of potassium channels. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blotting applications. By targeting the KCNK17 protein, researchers can accurately detect and analyze its expression in a variety of cell types, making it an essential component of studies in the fields of neuroscience and cardiovascular biology.KCNK17, also known as TASK-4, plays a crucial role in regulating the electrical excitability of cells by controlling potassium ion flow.
Its involvement in processes such as cell proliferation, apoptosis, and hormone secretion underscores its importance in various physiological functions. Furthermore, dysregulation of KCNK17 function has been linked to disorders like epilepsy, arrhythmias, and hypertension, highlighting its potential as a therapeutic target in the treatment of these conditions. By gaining insights into the role of KCNK17, researchers can pave the way for the development of novel interventions that target potassium channels for therapeutic benefit.
Antibody Name:
KCNK17 Antibody (PACO05656)
Antibody SKU:
PACO05656
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:20000, WB:1:500-1:2000
Species Reactivity:
Human
Immunogen:
Synthesized peptide derived from the C-terminal region of human TALK-2.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
KCNK17; TALK2; TASK4; Potassium channel subfamily K member 17; 2P domain potassium channel Talk-2; Acid-sensitive potassium channel protein TASK-4; TWIK-related acid-sensitive K(+) channel 4; TWIK-related alkaline pH-activated K(+) channel
UniProt Protein Function:
KCNK17: Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K(+) currents. Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.Protein type: Membrane protein, integral; Membrane protein, multi-passChromosomal Location of Human Ortholog: 6p21.2Cellular Component: integral component of plasma membrane; plasma membraneMolecular Function: potassium channel activity; potassium ion leak channel activity; voltage-gated ion channel activityBiological Process: potassium ion transport; stabilization of membrane potential
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene belongs to the family of potassium channel proteins containing two pore-forming P domains. This channel is an open rectifier which primarily passes outward current under physiological K+ concentrations. This gene is activated at alkaline pH. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]
