The KCNK16 Polyclonal Antibody (PAC046958) is a valuable tool for researchers studying KCNK16, a potassium channel protein involved in the regulation of cell membrane potential and ion transport. This antibody, produced in rabbits, exhibits high reactivity with human samples and is suitable for Western blot applications. By targeting the KCNK16 protein, this antibody enables the detection and analysis of this crucial ion channel in a variety of cell types, making it an essential component for studies in physiology and neuroscience.KCNK16, also known as TWIK-related potassium channel, plays a pivotal role in controlling the electrical properties of cells and influencing various physiological processes such as neuronal excitability and vascular tone regulation.
Dysregulation of KCNK16 has been linked to conditions like epilepsy, cardiac arrhythmias, and hypertension, underscoring its importance in health and disease. Investigating the function of KCNK16 is essential for advancing our understanding of these disorders and developing targeted therapies to address them.
Antibody Name:
KCNK16 Antibody (PACO46958)
Antibody SKU:
PACO46958
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:20-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human Potassium channel subfamily K member 16 protein (259-309AA)
Potassium channel subfamily K member 16 (2P domain potassium channel Talk-1) (TWIK-related alkaline pH-activated K(+) channel 1) (TALK-1), KCNK16, TALK1
UniProt Protein Function:
KCNK16: Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K(+) currents. Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. 4 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integral; Membrane protein, multi-passChromosomal Location of Human Ortholog: 6p21.2Cellular Component: integral component of plasma membrane; plasma membraneMolecular Function: potassium channel activity; potassium ion leak channel activity; protein binding; voltage-gated ion channel activityBiological Process: potassium ion transport; stabilization of membrane potential
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene belongs to the family of potassium channel proteins containing two pore-forming P domains. This channel is an open rectifier which primarily passes outward current under physiological K+ concentrations. This gene is expressed predominantly in the pancreas and is activated at alkaline pH. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Sep 2008]
