The KCNK13 Polyclonal Antibody (PACO40450) is a valuable tool for researchers studying the KCNK13 gene, which encodes a member of the two-pore domain potassium channel family. This antibody, raised in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By binding to the KCNK13 protein, this antibody allows for the detection and analysis of KCNK13 expression in various cell types.The KCNK13 gene plays a crucial role in potassium ion transport and cell membrane potential regulation. Dysregulation of KCNK13 has been implicated in various diseases, including neurological disorders, cardiovascular diseases, and cancer.
By studying the expression and function of KCNK13, researchers can gain valuable insights into the underlying mechanisms of these conditions and potentially identify new therapeutic targets.Overall, the KCNK13 Polyclonal Antibody is a powerful tool for investigating the role of KCNK13 in health and disease. Its high specificity and sensitivity make it ideal for use in research settings focused on understanding the functions of potassium channels and their implications for human health.
Western blot. All lanes: KCNK13 antibody at 8µg/ml. Lane 1: HepG2 whole cell lysate. Lane 2: LO2 whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 46 kDa. Observed band size: 46 kDa.
Immunohistochemistry of paraffin-embedded human glioma using PACO40450 at dilution of 1:100.
Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using PACO40450 at dilution of 1:100.
Background:
Potassium channel displaying weak inward rectification in symmetrical K(+) solution.
Synonyms:
Potassium channel subfamily K member 13 (Tandem pore domain halothane-inhibited potassium channel 1) (THIK-1), KCNK13
UniProt Protein Function:
KCNK13: Potassium channel displaying weak inward rectification in symmetrical K(+) solution. Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.Protein type: Membrane protein, multi-pass; Membrane protein, integralChromosomal Location of Human Ortholog: 14q32.11Cellular Component: integral to membrane; plasma membraneMolecular Function: potassium channel activity; voltage-gated ion channel activityBiological Process: synaptic transmission
UniProt Protein Details:
NCBI Summary:
Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a potassium channel containing two pore-forming domains. This protein is an open channel that can be stimulated by arachidonic acid and inhibited by the anesthetic halothane. [provided by RefSeq, Jul 2013]
