The KCNK12 Antibody (PAC02559) is a valuable tool for researchers studying the KCNK12 gene, which encodes the K2p12.1 potassium channel. This antibody, produced in rabbits, exhibits high specificity and sensitivity towards human samples, making it ideal for Western blot applications. By binding to the KCNK12 protein, the antibody allows for the detection and analysis of this potassium channel in various cell types, providing valuable insights into its role in physiology and pathophysiology.The K2p12.1 potassium channel is known for its involvement in the regulation of cellular excitability and ion transport, making it a potential target for therapeutic interventions in conditions such as epilepsy, pain, and cardiac arrhythmias.
Research on the KCNK12 gene and its protein product is essential for understanding the mechanisms underlying these diseases and developing novel treatment strategies.Overall, the KCNK12 Antibody (PAC02559) offers researchers a reliable tool for investigating the function and regulation of the K2p12.1 potassium channel, paving the way for advancements in the fields of neuroscience, cardiology, and pharmacology.
Antibody Name:
KCNK12 Antibody (PACO22509)
Antibody SKU:
PACO22509
Size:
100ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:10000, WB:1:500-1:3000
Species Reactivity:
Human
Immunogen:
Synthesized peptide derived from C-terminal of human KCNK12.
Form:
Liquid
Storage Buffer:
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Western blot analysis of extracts from Rat Muscle cells, using KCNK12 antibody.
Background:
Probable potassium channel subunit. No channel activity observed in heterologous systems. May need to associate with another protein to form a functional channel By similarity.
Synonyms:
Potassium channel subfamily K member 12; Tandem pore domain halothane-inhibited potassium channel 2; THIK-2;
UniProt Protein Function:
KCNK12: Probable potassium channel subunit. No channel activity observed in heterologous systems. May need to associate with another protein to form a functional channel. Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.Protein type: Membrane protein, integral; Membrane protein, multi-passChromosomal Location of Human Ortholog: 2p16.3Cellular Component: integral to plasma membraneMolecular Function: potassium ion leak channel activityBiological Process: stabilization of membrane potential
UniProt Protein Details:
NCBI Summary:
This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The product of this gene has not been shown to be a functional channel, however, it may require other non-pore-forming proteins for activity. [provided by RefSeq, Jul 2008]
