The KCNK12 Polyclonal Antibody (PAC04782) is a valuable tool for researchers studying the KCNK12 protein, a member of the two-pore domain potassium channel family implicated in various cellular processes, including ion transport and neuronal excitability. This antibody, generated in rabbits, is highly specific to human samples and has been validated for Western blot applications. By specifically binding to the KCNK12 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it an ideal choice for studies in neuroscience and physiology.KCNK12, also known as TWIK-1, plays a crucial role in regulating potassium ion conduction and membrane potential in neurons, making it a key player in neuronal excitability and neurotransmitter release.
Understanding the function and regulation of KCNK12 is essential for unraveling the mechanisms underlying neuronal signaling and identifying potential targets for neurological disorders and conditions such as epilepsy and chronic pain.The KCNK12 Polyclonal Antibody (PAC04782) offers researchers a reliable tool for investigating the role of KCNK12 in cellular physiology and neurological function, paving the way for new insights and potential therapeutic strategies in the field of neuroscience.
Antibody Name:
KCNK12 Antibody
Antibody SKU:
PACO04782
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
WB:1:500-1:2000
Species Reactivity:
Human, Mouse, Rat
Immunogen:
synthesized peptide derived from the C-terminal region of human THIK-2.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
KCNK12; Potassium channel subfamily K member 12; Tandem pore domain halothane-inhibited potassium channel 2; THIK-2
UniProt Protein Function:
KCNK12: Probable potassium channel subunit. No channel activity observed in heterologous systems. May need to associate with another protein to form a functional channel. Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.Protein type: Membrane protein, integral; Membrane protein, multi-passChromosomal Location of Human Ortholog: 2p16.3Cellular Component: integral to plasma membraneMolecular Function: potassium ion leak channel activityBiological Process: stabilization of membrane potential
UniProt Protein Details:
NCBI Summary:
This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The product of this gene has not been shown to be a functional channel, however, it may require other non-pore-forming proteins for activity. [provided by RefSeq, Jul 2008]
