The KCNJ2 Polyclonal Antibody (CAB12949) is a valuable tool for researchers studying the KCNJ2 gene, which encodes for the inward rectifier potassium channel Kir2.1. This antibody, produced in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By binding to the KCNJ2 protein, this antibody allows for accurate detection and analysis in a variety of cell types, making it ideal for investigations in physiology, neuroscience, and cardiovascular research.The Kir2.1 channel, encoded by the KCNJ2 gene, plays a crucial role in regulating the resting membrane potential and electrical excitability of cells, particularly in the heart and nervous system.
Mutations in KCNJ2 have been associated with various cardiac arrhythmias and neurological disorders, making it a significant target for research into these conditions. Understanding the function and regulation of Kir2.1 channels is essential for developing targeted therapies for diseases related to ion channel dysfunction. Overall, the KCNJ2 Polyclonal Antibody (CAB12949) provides researchers with a reliable tool for investigating the role of KCNJ2 in health and disease, offering insights that may lead to the development of new treatments and interventions in the future.
Product Name:
KCNJ2 Rabbit Polyclonal Antibody
SKU:
CAB12949
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 318-427 of human KCNJ2 (NP_000882.1).
Sequence:
NEIL WGHR YEPV LFEE KHYY KVDY SRFH KTYE VPNT PLCS ARDL AEKK YILS NANS FCYE NEVA LTSK EEDD SENG VPES TSTD TPPD IDLH NQAS VPLE PRPL RRES EI
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Mutations in this gene have been associated with Andersen syndrome, which is characterized by periodic paralysis, cardiac arrhythmias, and dysmorphic features.
Purification Method:
Affinity purification
Gene ID:
3759
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using KCNJ2 Rabbit pAb (CAB12949) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
