The KCNJ12 Polyclonal Antibody (CAB14375) is a valuable tool for research involving the KCNJ12 protein, which plays a key role in regulating potassium ion channels in various cell types. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding to the KCNJ12 protein, this antibody enables researchers to detect and analyze its expression in cells, making it ideal for studies in physiology, neuroscience, and cardiovascular research.KCNJ12, also known as Kir2.2, is a member of the inwardly rectifying potassium channel family and is involved in maintaining membrane potential and regulating cell excitability.
Dysregulation of KCNJ12 has been implicated in various diseases, including cardiac arrhythmias, epilepsy, and neurological disorders. Investigating the function of KCNJ12 is essential for understanding its role in these conditions and developing targeted therapies to modulate potassium channel activity.Overall, the KCNJ12 Polyclonal Antibody (CAB14375) is a reliable tool for researchers studying potassium ion channels and their impact on cellular function and disease. Its specificity and sensitivity make it a valuable asset for advancing our understanding of KCNJ12 biology and its potential as a therapeutic target.
Product Name:
KCNJ12 Rabbit Polyclonal Antibody
SKU:
CAB14375
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 354-433 of human KCNJ12 (NP_066292.2).
This gene encodes an inwardly rectifying K+ channel which may be blocked by divalent cations. This protein is thought to be one of multiple inwardly rectifying channels which contribute to the cardiac inward rectifier current (IK1). The gene is located within the Smith-Magenis syndrome region on chromosome 17.
Purification Method:
Affinity purification
Gene ID:
3768
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using KCNJ12 Rabbit pAb (CAB14375) at 1:300 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
