The KCNJ10 Polyclonal Antibody (CAB9826) is a valuable tool for researchers studying KCNJ10, a potassium channel protein that plays a critical role in various cellular processes, including potassium ion transport and cell signaling. This antibody, produced in rabbits, exhibits excellent reactivity with human samples and has been validated for use in Western blot applications.KCNJ10, also known as Kir4.1, is primarily expressed in the brain, kidneys, and inner ear, where it helps maintain potassium homeostasis and regulate neuronal excitability. Dysregulation of KCNJ10 has been linked to a variety of neurological disorders, making it a promising target for drug development and therapeutic interventions.
By specifically binding to KCNJ10, this antibody enables precise detection and analysis of the protein in different cell types and tissues, making it an essential tool for studies in neuroscience, nephrology, and drug discovery. Understanding the function and regulation of KCNJ10 is crucial for advancing our knowledge of potassium channel biology and developing novel treatments for neurological diseases and kidney disorders.
Product Name:
KCNJ10 Rabbit Polyclonal Antibody
SKU:
CAB9826
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 50-150 of human KCNJ10 (NP_002232.2).
This gene encodes a member of the inward rectifier-type potassium channel family, characterized by having a greater tendency to allow potassium to flow into, rather than out of, a cell. The encoded protein may form a heterodimer with another potassium channel protein and may be responsible for the potassium buffering action of glial cells in the brain. Mutations in this gene have been associated with seizure susceptibility of common idiopathic generalized epilepsy syndromes.
Purification Method:
Affinity purification
Gene ID:
3766
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using KCNJ10 Antibody (CAB9826) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
