The KCNIP4 Polyclonal Antibody (PACO10055) is a valuable tool for researchers studying potassium voltage-gated channel-interacting protein 4 (KCNIP4). This cell surface molecule is involved in regulating ion channels and neuronal excitability, making it a key player in neuronal function and communication. The antibody, produced in rabbits, is highly specific to human samples and is validated for use in Western blot applications. By binding to KCNIP4, researchers can effectively study its expression and function in various cell types, providing insight into its role in neurological disorders and brain function.KCNIP4 is known for its involvement in modulating potassium channels and shaping action potentials in neurons, making it a potential target for therapeutic interventions in conditions such as epilepsy, Alzheimer's disease, and other neurological disorders.
Understanding the molecular mechanisms of KCNIP4 can lead to the development of targeted treatments that regulate neuronal excitability and synaptic transmission. By using the KCNIP4 Polyclonal Antibody, researchers can further investigate the biological functions of KCNIP4 and uncover its potential implications in neurobiology and neurodegenerative diseases.
Kv channel interacting protein 4;KCNIP4;CALP;KCHIP4;MGC44947 ;
UniProt Protein Function:
KCNIP4: Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Probably modulates channels density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, modulates KCND2/Kv4.2 and KCND3/Kv4.3 currents. Belongs to the recoverin family. 5 isoforms of the human protein are produced by alternative splicing.Chromosomal Location of Human Ortholog: 4p15.32Cellular Component: cytoplasm; cytosol; plasma membrane; voltage-gated potassium channel complexMolecular Function: calcium ion binding; potassium channel regulator activity
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belong to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. This protein member also interacts with presenilin. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
