The KCNIP4 Polyclonal Antibody (PACO36894) is a vital tool for researchers studying the potassium channel interacting protein 4 (KCNIP4). This antibody, produced in rabbits, exhibits high reactivity with human samples and is specifically validated for use in Western blot applications. By binding to the KCNIP4 protein, this antibody enables precise detection and analysis in a variety of cell types, making it an excellent choice for investigations in neuroscience and cardiovascular research.KCNIP4 is a key player in regulating potassium channels in the brain and heart, influencing electrical signaling and excitability of neurons and cardiomyocytes.
Dysregulation of KCNIP4 has been implicated in neurological disorders such as epilepsy and cardiac arrhythmias, highlighting its importance in maintaining proper functioning of the nervous and cardiovascular systems. Research into KCNIP4 is crucial for developing targeted therapies to treat these conditions and improve patient outcomes.Invest in the KCNIP4 Polyclonal Antibody (PACO36894) to unlock new insights into the role of KCNIP4 in health and disease, paving the way for innovative treatment strategies in neuroscience and cardiology.
Immunohistochemistry of paraffin-embedded human brain tissue using PACO36894 at dilution of 1:100.
Immunofluorescent analysis of Hela cells using PACO36894 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:
Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Modulates KCND2 channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. Modulates KCND3/Kv4.3 currents. Isoform 4 does not increase KCND2 expression at the cell membrane. Isoform 4 retains KCND3 in the endoplasmic reticulum and negatively regulates its expression at the cell membrane.
Synonyms:
Kv channel-interacting protein 4 (KChIP4) (A-type potassium channel modulatory protein 4) (Calsenilin-like protein) (Potassium channel-interacting protein 4), KCNIP4, CALP KCHIP4
UniProt Protein Function:
KCNIP4: Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Probably modulates channels density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, modulates KCND2/Kv4.2 and KCND3/Kv4.3 currents. Belongs to the recoverin family. 5 isoforms of the human protein are produced by alternative splicing.Chromosomal Location of Human Ortholog: 4p15.32Cellular Component: cytoplasm; cytosol; plasma membrane; voltage-gated potassium channel complexMolecular Function: calcium ion binding; potassium channel regulator activity
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belong to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. This protein member also interacts with presenilin. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
