Anti-KCNH8 Antibody (PACO18046)

Antibody Name:	KCNH8 Antibody (PACO18046)
Antibody SKU:	PACO18046
Size:	50ul
Host Species:	Rabbit
Tested Applications:	ELISA, IHC
Recommended Dilutions:	ELISA:1:1000-1:5000, IHC:1:25-1:100
Species Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic peptide of human KCNH8

Form:	Liquid
Storage Buffer:	-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:	Antigen affinity purification
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

	The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO18046(KCNH8 Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: x200).
	The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using PACO18046(KCNH8 Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: x200).

Background:

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit.

Synonyms:

potassium voltage-gated channel, subfamily H (eag-related), member 8

UniProt Protein Function:	KCNH8: Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits a slowly activating, outward rectifying current. Channel properties may be modulated by cAMP and subunit assembly. Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv12.1/KCNH8 sub-subfamily.Protein type: Membrane protein, integral; Membrane protein, multi-passCellular Component: membrane; integral to plasma membrane; integral to membraneMolecular Function: RNA polymerase II transcription factor activity, enhancer binding; signal transducer activity; voltage-gated potassium channel activity; potassium channel activity; ion channel activity; voltage-gated ion channel activity; two-component sensor activityBiological Process: regulation of transcription from RNA polymerase II promoter; transcription from RNA polymerase II promoter; regulation of membrane potential; transport; two-component signal transduction system (phosphorelay); ion transport; signal transduction; transmembrane transport; potassium ion transport; negative regulation of apoptosis
UniProt Protein Details:
NCBI Summary:
UniProt Code:	Q96L42
NCBI GenInfo Identifier:	120538754
NCBI Gene ID:	211468
NCBI Accession:	NP_653234
UniProt Secondary Accession:	Q96L42,Q8BX82
UniProt Related Accession:	Q96L42,P59111
Molecular Weight:	123,277 Da
NCBI Full Name:	Kcnh8 protein
NCBI Synonym Full Names:	potassium voltage-gated channel, subfamily H (eag-related), member 8
NCBI Official Symbol:	Kcnh8
NCBI Official Synonym Symbols:	ELK; ELK1; ELK3; Kv12.1; C130090D05Rik
NCBI Protein Information:	potassium voltage-gated channel subfamily H member 8; ELK channel 3; ether-a-go-go-like potassium channel 3; potassium voltage-gated channel, subfamily H, member 8; voltage-gated potassium channel subunit Kv12.1
UniProt Protein Name:	Potassium voltage-gated channel subfamily H member 8
UniProt Synonym Protein Names:	Ether-a-go-go-like potassium channel 3; ELK channel 3; ELK3; Voltage-gated potassium channel subunit Kv12.1
Protein Family:	Potassium voltage-gated channel subfamily
UniProt Gene Name:	Kcnh8
UniProt Entry Name:	KCNH8_MOUSE

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)