KCNH8 Antibody (PACO18045)
- SKU:
- PACO18045
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Frequently bought together:
Description
| Antibody Name: | KCNH8 Antibody (PACO18045) |
| Antibody SKU: | PACO18045 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:1000-1:2000, IHC:1:10-1:50 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Synthetic peptide of human KCNH8 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO18045(KCNH8 Antibody) at dilution 1/15, on the right is treated with synthetic peptide. (Original magnification: x200). |
 | The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO18045(KCNH8 Antibody) at dilution 1/15, on the right is treated with synthetic peptide. (Original magnification: x200). |
| Background: | Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit. |
| Synonyms: | potassium voltage-gated channel, subfamily H (eag-related), member 8 |
| UniProt Protein Function: | KCNH8: Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits a slowly activating, outward rectifying current. Channel properties may be modulated by cAMP and subunit assembly. Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv12.1/KCNH8 sub-subfamily.Protein type: Membrane protein, integral; Membrane protein, multi-passCellular Component: membrane; integral to plasma membrane; integral to membraneMolecular Function: RNA polymerase II transcription factor activity, enhancer binding; signal transducer activity; voltage-gated potassium channel activity; potassium channel activity; ion channel activity; voltage-gated ion channel activity; two-component sensor activityBiological Process: regulation of transcription from RNA polymerase II promoter; transcription from RNA polymerase II promoter; regulation of membrane potential; transport; two-component signal transduction system (phosphorelay); ion transport; signal transduction; transmembrane transport; potassium ion transport; negative regulation of apoptosis |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q96L42 |
| NCBI GenInfo Identifier: | 120538754 |
| NCBI Gene ID: | 211468 |
| NCBI Accession: | NP_653234 |
| UniProt Secondary Accession: | Q96L42,Q8BX82 |
| UniProt Related Accession: | Q96L42,P59111 |
| Molecular Weight: | 123,277 Da |
| NCBI Full Name: | Kcnh8 protein |
| NCBI Synonym Full Names: | potassium voltage-gated channel, subfamily H (eag-related), member 8 |
| NCBI Official Symbol: | Kcnh8Â Â |
| NCBI Official Synonym Symbols: | ELK; ELK1; ELK3; Kv12.1; C130090D05Rik  |
| NCBI Protein Information: | potassium voltage-gated channel subfamily H member 8; ELK channel 3; ether-a-go-go-like potassium channel 3; potassium voltage-gated channel, subfamily H, member 8; voltage-gated potassium channel subunit Kv12.1 |
| UniProt Protein Name: | Potassium voltage-gated channel subfamily H member 8 |
| UniProt Synonym Protein Names: | Ether-a-go-go-like potassium channel 3; ELK channel 3; ELK3; Voltage-gated potassium channel subunit Kv12.1 |
| Protein Family: | Potassium voltage-gated channel subfamily |
| UniProt Gene Name: | Kcnh8Â Â |
| UniProt Entry Name: | KCNH8_MOUSE |
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