| UniProt Protein Function: | Kv10.2: Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits a non-inactivating outward rectifying current. Channel properties may be modulated by cAMP and subunit assembly. Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv10.2/KCNH5 sub-subfamily. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Channel, potassium; Membrane protein, multi-pass; Membrane protein, integralChromosomal Location of Human Ortholog: 14q23.2Cellular Component: cell surface; integral to membrane; intracellular; plasma membraneMolecular Function: calmodulin binding; protein heterodimerization activity; two-component sensor activity; voltage-gated potassium channel activityBiological Process: regulation of G2/M transition of mitotic cell cycle; regulation of membrane potential; synaptic transmission; two-component signal transduction system (phosphorelay) |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a member of voltage-gated potassium channels. Members of this family have diverse functions, including regulating neurotransmitter and hormone release, cardiac function, and cell volume. This protein is an outward-rectifying, noninactivating channel. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013] |
| UniProt Code: | Q8NCM2 |
| NCBI GenInfo Identifier: | 334302891 |
| NCBI Gene ID: | 238271 |
| NCBI Accession: | Q8NCM2.3 |
| UniProt Secondary Accession: | Q8NCM2,C9JP98 |
| UniProt Related Accession: | Q8NCM2 |
| Molecular Weight: | |
| NCBI Full Name: | Potassium voltage-gated channel subfamily H member 5 |
| NCBI Synonym Full Names: | potassium voltage-gated channel subfamily H member 5 |
| NCBI Official Symbol: | KCNH5Â Â |
| NCBI Official Synonym Symbols: | EAG2; hEAG2; H-EAG2; Kv10.2Â Â |
| NCBI Protein Information: | potassium voltage-gated channel subfamily H member 5 |
| UniProt Protein Name: | Potassium voltage-gated channel subfamily H member 5 |
| UniProt Synonym Protein Names: | Ether-a-go-go potassium channel 2; hEAG2; Voltage-gated potassium channel subunit Kv10.2 |
| Protein Family: | Potassium voltage-gated channel subfamily |
| UniProt Gene Name: | KCNH5Â Â |
| UniProt Entry Name: | KCNH5_HUMAN |
