The KCNH5 Polyclonal Antibody (PACO07193) is a valuable tool for researchers studying the KCNH5 protein, a member of the potassium voltage-gated channel subfamily H. This antibody, raised in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By recognizing and binding to the KCNH5 protein, this antibody enables precise detection and analysis in a variety of cell types, making it ideal for research in neuroscience and cardiovascular biology.
The KCNH5 protein is essential for regulating the electrical activity of cells, particularly in the heart and nervous system. Dysregulation of KCNH5 has been implicated in various cardiovascular disorders and neurological conditions, making it a promising target for therapeutic interventions. Understanding the function and expression of KCNH5 is crucial for advancing our knowledge of these diseases and developing innovative treatment strategies.
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Immunohistochemical analysis of paraffin-embedded Rat BrainTissue using Kv10.2 Rabbit pAb diluted at 1:200.
Immunohistochemical analysis of paraffin-embedded Mouse BrainTissue using Kv10.2 Rabbit pAb diluted at 1:200.
Western blot analysis of 1) Rat Brain Tissue-Low Molecular Protein Marker, 2)Rat Brain Tissue-High Molecular Protein Marker, 3) Mouse Brain Tissue-Low Molecular Protein Marker, 4) Mouse Brain Tissue- High Molecular Protein Marker, 5) HepG2-Low Molecular P.
UniProt Protein Function:
Kv10.2: Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits a non-inactivating outward rectifying current. Channel properties may be modulated by cAMP and subunit assembly. Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv10.2/KCNH5 sub-subfamily. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Channel, potassium; Membrane protein, multi-pass; Membrane protein, integralChromosomal Location of Human Ortholog: 14q23.2Cellular Component: cell surface; integral to membrane; intracellular; plasma membraneMolecular Function: calmodulin binding; protein heterodimerization activity; two-component sensor activity; voltage-gated potassium channel activityBiological Process: regulation of G2/M transition of mitotic cell cycle; regulation of membrane potential; synaptic transmission; two-component signal transduction system (phosphorelay)
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of voltage-gated potassium channels. Members of this family have diverse functions, including regulating neurotransmitter and hormone release, cardiac function, and cell volume. This protein is an outward-rectifying, noninactivating channel. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
