KCNH3 Antibody (PACO18044)
- SKU:
- PACO18044
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | KCNH3 Antibody (PACO18044) |
Antibody SKU: | PACO18044 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:1000-1:2000, IHC:1:10-1:50 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Synthetic peptide of human KCNH3 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO18044(KCNH3 Antibody) at dilution 1/12, on the right is treated with synthetic peptide. (Original magnification: x200). |
Background: | Potassium voltage-gated channel subfamily H member 3 is a protein that in humans is encoded by the KCNH3 gene. The protein encoded by this gene is a voltage-gated potassium channel subunit. Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits an outward current with fast inactivation. Channel properties may be modulated by cAMP and subunit assembly. The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming α subunits that can associate with modulating β subunits. Detected only in brain, in particular in the telencephalon. Detected in the cerebral cortex, occipital pole, frontal and temporal lobe, putamen, amygdala, hippocampus and caudate nucleus. |
Synonyms: | potassium voltage-gated channel, subfamily H (eag-related), member 3 |
UniProt Protein Function: | Kv12.2: Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits an outward current with fast inactivation. Channel properties may be modulated by cAMP and subunit assembly. Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv12.2/KCNH3 sub-subfamily.Protein type: Membrane protein, multi-pass; Membrane protein, integralChromosomal Location of Human Ortholog: 12q13Cellular Component: integral to plasma membrane; integral to membrane; plasma membraneMolecular Function: protein binding; voltage-gated potassium channel activity; two-component sensor activityBiological Process: synaptic transmission; regulation of membrane potential; two-component signal transduction system (phosphorelay); potassium ion transport |
UniProt Protein Details: | |
NCBI Summary: | The protein encoded by this gene is a voltage-gated potassium channel alpha subunit predominantly expressed in the forebrain. Studies in mice have found that cognitive function increases when this gene is knocked out. In humans, the encoded protein has been shown to be capable of binding glycoprotein 120 of the human immunodeficiency virus type 1 (HIV-1) envelope. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015] |
UniProt Code: | Q9ULD8 |
NCBI GenInfo Identifier: | 38569493 |
NCBI Gene ID: | 23416 |
NCBI Accession: | NP_036416 |
UniProt Secondary Accession: | Q9ULD8 |
UniProt Related Accession: | Q9ULD8 |
Molecular Weight: | 117kDa |
NCBI Full Name: | potassium voltage-gated channel subfamily H member 3 isoform 1 |
NCBI Synonym Full Names: | potassium voltage-gated channel subfamily H member 3 |
NCBI Official Symbol: | KCNH3Â Â |
NCBI Official Synonym Symbols: | BEC1; ELK2; Kv12.2Â Â |
NCBI Protein Information: | potassium voltage-gated channel subfamily H member 3 |
UniProt Protein Name: | Potassium voltage-gated channel subfamily H member 3 |
UniProt Synonym Protein Names: | Brain-specific eag-like channel 1; BEC1; Ether-a-go-go-like potassium channel 2; ELK channel 2; ELK2; Voltage-gated potassium channel subunit Kv12.2 |
Protein Family: | Potassium voltage-gated channel subfamily |
UniProt Gene Name: | KCNH3Â Â |
UniProt Entry Name: | KCNH3_HUMAN |
Antibodies |
KCNH3 Antibody (PACO03700) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |