The KCNH2 Polyclonal Antibody (CAB2968) is a valuable tool for researchers studying the KCNH2 gene, which encodes the hERG potassium channel. This antibody, produced in rabbits, has been validated for use in various applications, including Western blot and immunohistochemistry.The hERG potassium channel plays a crucial role in the heart, regulating the repolarization of cardiac action potentials. Mutations in the KCNH2 gene can lead to Long QT Syndrome, a condition characterized by an increased risk of life-threatening arrhythmias. By using the KCNH2 Polyclonal Antibody, researchers can study the expression and localization of the hERG channel in different tissues and cell types, contributing to our understanding of cardiac function and potential therapeutic targets.
Furthermore, studying the KCNH2 gene and hERG channel is essential for drug development, as many pharmaceutical compounds can interact with this channel, leading to potential adverse effects on cardiac function. By using the CAB2968 antibody, researchers can explore the impact of new drugs on the hERG channel, aiding in the development of safer and more effective treatments for various conditions.
Product Name:
KCNH2 Rabbit Polyclonal Antibody
SKU:
CAB2968
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 850-950 of human KCNH2 (NP_000229.1).
This gene encodes a component of a voltage-activated potassium channel found in cardiac muscle, nerve cells, and microglia. Four copies of this protein interact with one copy of the KCNE2 protein to form a functional potassium channel. Mutations in this gene can cause long QT syndrome type 2 (LQT2). Transcript variants encoding distinct isoforms have been identified.
Purification Method:
Affinity purification
Gene ID:
3757
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using KCNH2 Rabbit pAb (CAB2968) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 30s.
