The KCNH1 Polyclonal Antibody (CAB6636) is a valuable tool for research involving the KCNH1 gene, which encodes a voltage-gated potassium channel known to play a role in neuronal excitability. This antibody, produced in rabbits, is highly specific for human samples and has been validated for use in applications such as Western blotting.The KCNH1 protein is essential for regulating the electrical activity of neurons, making it an important target for studies in neuroscience and neurology. Dysregulation of KCNH1 has been associated with neurological disorders such as epilepsy and autism, highlighting the importance of understanding its function.
By using the KCNH1 Polyclonal Antibody, researchers can explore the expression levels and localization of KCNH1 in various cell types and tissues, providing insight into its role in neuronal function and potential implications for disease pathology. This antibody is a valuable tool for investigating the molecular mechanisms underlying neurological disorders and may ultimately contribute to the development of novel therapeutic strategies.
Product Name:
KCNH1 Rabbit Polyclonal Antibody
SKU:
CAB6636
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 813-962 of human KCNH1 (NP_002229.1).
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit of a voltage-gated non-inactivating delayed rectifier potassium channel. It is activated at the onset of myoblast differentiation. The gene is highly expressed in brain and in myoblasts. Overexpression of the gene may confer a growth advantage to cancer cells and favor tumor cell proliferation. Alternative splicing of this gene results in two transcript variants encoding distinct isoforms.
Purification Method:
Affinity purification
Gene ID:
3756
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using KCNH1 antibody (CAB6636) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
