The KCNG3 Polyclonal Antibody (PACO2583) is essential for research involving KCNG3, a voltage-gated potassium channel subunit that plays a crucial role in regulating neuronal excitability. The antibody, produced in rabbits, demonstrates high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the KCNG3 protein, this antibody enables accurate detection and analysis in various cell types, making it an ideal tool for studies in neurobiology and brain disorders.KCNG3 is known to modulate potassium currents in neurons, influencing action potential firing and synaptic transmission. Its involvement in neuronal function highlights its importance in conditions such as epilepsy, schizophrenia, and neuropathic pain.
Research into the mechanisms of KCNG3 can provide insights into these neurological disorders and pave the way for targeted therapeutic interventions aimed at alleviating symptoms and improving patient outcomes.Overall, the KCNG3 Polyclonal Antibody (PACO2583) offers a valuable asset for scientists seeking to unravel the complexities of neuronal excitability and explore the potential role of KCNG3 in neurological diseases. Its specificity and reliability make it a valuable tool for investigating the function and regulation of this potassium channel subunit in health and disease.
Antibody Name:
KCNG3 Antibody
Antibody SKU:
PACO02583
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
WB:1:500-1:2000
Species Reactivity:
Human, Mouse, Rat
Immunogen:
synthesized peptide derived from the Internal region of human KCNG3.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
KCNG3; Potassium voltage-gated channel subfamily G member 3; Voltage-gated potassium channel subunit Kv10.1; Voltage-gated potassium channel subunit Kv6.3
UniProt Protein Function:
KCNG3: Potassium channel subunit. Modulates channel activity. Belongs to the potassium channel family. G (TC 1.A.1.2) subfamily. Kv6.3/KCNG3 sub-subfamily. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, multi-pass; Membrane protein, integralChromosomal Location of Human Ortholog: 2p21Cellular Component: endoplasmic reticulum; plasma membrane; voltage-gated potassium channel complexMolecular Function: delayed rectifier potassium channel activity; protein binding
UniProt Protein Details:
NCBI Summary:
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily G. This member is a gamma subunit functioning as a modulatory molecule. Alternative splicing results in two transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
