The KCNG2 Antibody (PAC019881) is a polyclonal antibody designed for research involving KCNG2, a protein known to play a key role in voltage-gated potassium channels. This antibody, raised in rabbits, is highly reactive with human samples and is validated for use in various applications including Western blot and immunohistochemistry.KCNG2 is a critical component of potassium channels in the heart and brain, contributing to the regulation of neuronal excitability and cardiac action potential. Dysregulation of KCNG2 has been associated with neurological disorders, cardiac arrhythmias, and potentially cancer development.
Therefore, studying the function and expression of KCNG2 is crucial for understanding its role in these disease contexts and potentially developing targeted therapies.With its high specificity and reactivity to KCNG2, the PAC019881 antibody is an essential tool for researchers investigating the biology and pathology related to voltage-gated potassium channels. Its ability to detect and analyze KCNG2 expression in various cell types makes it a valuable asset for studies in neuroscience, cardiology, and cancer research. Unlock the potential of your research with the KCNG2 Antibody from AssayGenie.
Antibody Name:
KCNG2 Antibody (PACO19881)
Antibody SKU:
PACO19881
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:5000, WB:1:500-1:2000
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Synthetic peptide of human KCNG2
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Mouse brain tissue, Primary antibody: PACO19881(KCNG2 Antibody) at dilution 1/650, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes.
Background:
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily G. This member is a γ subunit of the voltage-gated potassium channel. The delayed-rectifier type channels containing this subunit may contribute to cardiac action potential repolarization.
Synonyms:
potassium voltage-gated channel, subfamily G, member 2
UniProt Protein Function:
Kv6.2: Potassium channel subunit. Modulates channel activity by shifting the threshold and the half-maximal activation to more negative values. Belongs to the potassium channel family. G (TC 1.A.1.2) subfamily. Kv6.2/KCNG2 sub-subfamily.Protein type: Membrane protein, multi-pass; Membrane protein, integralChromosomal Location of Human Ortholog: 18q23Cellular Component: plasma membraneMolecular Function: delayed rectifier potassium channel activityBiological Process: potassium ion transport; regulation of heart contraction; regulation of insulin secretion
UniProt Protein Details:
NCBI Summary:
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily G. This member is a gamma subunit of the voltage-gated potassium channel. The delayed-rectifier type channels containing this subunit may contribute to cardiac action potential repolarization. [provided by RefSeq, Jul 2008]
