The KCNG2 Monoclonal Antibody (PACO00993) is a cutting-edge tool for researchers studying the KCNG2 protein, a key player in ion channel function and neuronal excitability. This antibody, developed using advanced monoclonal antibody technology, offers high specificity and sensitivity for detecting KCNG2 in various experimental settings, including Western blot and immunofluorescence.KCNG2, also known as the voltage-gated potassium channel subunit Kv6.2, plays a critical role in regulating neuronal membrane potential and excitability. Dysfunction of KCNG2 has been implicated in neurological disorders such as epilepsy and schizophrenia, making it a promising therapeutic target for drug development and treatment strategies.
By utilizing the KCNG2 Monoclonal Antibody, researchers can gain valuable insights into the function and regulation of KCNG2 in normal physiology and disease states. This antibody's exceptional performance and reliability make it an indispensable tool for neuroscience and neurology research, paving the way for new discoveries and advancements in the field.
Antibody Name:
KCNG2 Antibody
Antibody SKU:
PACO00993
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
WB:1:500-1:2000
Species Reactivity:
Human, Mouse, Rat
Immunogen:
synthesized peptide derived from the Internal region of human KCNG2.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
KCNG2; KCNF2; Potassium voltage-gated channel subfamily G member 2; Cardiac potassium channel subunit; Voltage-gated potassium channel subunit Kv6.2
UniProt Protein Function:
Kv6.2: Potassium channel subunit. Modulates channel activity by shifting the threshold and the half-maximal activation to more negative values. Belongs to the potassium channel family. G (TC 1.A.1.2) subfamily. Kv6.2/KCNG2 sub-subfamily.Protein type: Membrane protein, multi-pass; Membrane protein, integralChromosomal Location of Human Ortholog: 18q23Cellular Component: plasma membraneMolecular Function: delayed rectifier potassium channel activityBiological Process: potassium ion transport; regulation of heart contraction; regulation of insulin secretion
UniProt Protein Details:
NCBI Summary:
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily G. This member is a gamma subunit of the voltage-gated potassium channel. The delayed-rectifier type channels containing this subunit may contribute to cardiac action potential repolarization. [provided by RefSeq, Jul 2008]
