The KCNE2 Polyclonal Antibody (CAB9859) is a powerful tool for researchers studying KCNE2, a protein involved in potassium ion channel regulation and cardiac function. This antibody, generated in rabbits, is highly specific for human samples and has been validated for use in Western blotting and immunofluorescence applications.KCNE2 is known to modulate the activity of potassium channels in cardiac muscle cells, impacting the duration and amplitude of action potentials. Dysregulation of KCNE2 has been linked to cardiac arrhythmias and other heart-related disorders, making it a promising target for therapeutic intervention.
By utilizing the KCNE2 Polyclonal Antibody, researchers can accurately detect and analyze the expression of KCNE2 in various cell types and tissues, allowing for a deeper understanding of its role in cardiac physiology and potential implications for cardiovascular disease. This antibody is a valuable tool for studies in cardiology, electrophysiology, and drug development aimed at targeting potassium channel function.
Product Name:
KCNE2 Rabbit Polyclonal Antibody
SKU:
CAB9859
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human KCNE2 (NP_751951.1).
Cell membrane, Single-pass type I membrane protein.
Calculated MW:
14kDa
Observed MW:
15kDa
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, isk-related subfamily. This member is a small integral membrane subunit that assembles with the KCNH2 gene product, a pore-forming protein, to alter its function. This gene is expressed in heart and muscle and the gene mutations are associated with cardiac arrhythmia.
Purification Method:
Affinity purification
Gene ID:
9992
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of U-251MG cells, using KCNE2 antibody (CAB9859) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
