Kcne2 Antibody (PACO27745)
- SKU:
- PACO27745
- Product Type:
- Antibody
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Kcne2 Antibody (PACO27745)
The KCNE2 Antibody (PAC027745) is a valuable tool for researchers studying the KCNE2 protein, a member of the voltage-gated potassium channel beta subunit family. The antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By targeting the KCNE2 protein, this antibody enables researchers to detect and analyze KCNE2 expression in various cell types, making it essential for studies in cardiology and neuroscience.KCNE2 plays a crucial role in regulating potassium ion channels in the heart and nervous system, impacting cardiac function and neuronal excitability.
Dysregulation of KCNE2 has been implicated in cardiac arrhythmias and neurological disorders, making it a promising target for therapeutic interventions. Understanding the function of KCNE2 is essential for developing treatments for conditions related to potassium channel dysfunction, highlighting the importance of research using the KCNE2 Antibody (PAC027745).
| Antibody Name: | Kcne2 Antibody (PACO27745) |
| Antibody SKU: | PACO27745 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA |
| Recommended Dilutions: | |
| Species Reactivity: | Rat |
| Immunogen: | Recombinant Rat Potassium voltage-gated channel subfamily E member 2 protein (1-123AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Background: | Ancillary protein that assembles as a β subunit with a voltage-gated potassium channel complex of pore-forming α subunits. Modulates the gating kinetics and enhances stability of the channel complex. Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 (PubMed:19219384). Associated with KCNH2/HERG is proposed to form the rapidly activating component of the delayed rectifying potassium current in heart (IKr). May associate with KCNQ2 and/or KCNQ3 and modulate the native M-type current. May associate with HCN1 and HCN2 and increase potassium current (By similarity). Interacts with KCNQ1; forms a heterooligomer complex leading to currents with an apparently instantaneous activation, a rapid deactivation process and a linear current-voltage relationship and decreases the amplitude of the outward current (By similarity). |
| Synonyms: | Potassium voltage-gated channel subfamily E member 2 (MinK-related peptide 1) (Minimum potassium ion channel-related peptide 1) (Potassium channel subunit β MiRP1), Kcne2 |
| UniProt Protein Function: | KCNE2: Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Associated with KCNH2/HERG is proposed to form the rapidly activating component of the delayed rectifying potassium current in heart (IKr). May associate with KCNQ2 and/or KCNQ3 and modulate the native M-type current. May associate with KCNQ1/KVLTQ1 and elicit a voltage-independent current. May associate with HCN1 and HCN2 and increase potassium current. Defects in KCNE2 are the cause of long QT syndrome type 6 (LQT6). Long QT syndromes are heart disorders characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to exercise or emotional stress. KCNE2 mutants form channels that open slowly and close rapidly, thereby diminishing potassium currents. Defects in KCNE2 are the cause of familial atrial fibrillation type 4 (ATFB4). Atrial fibrillation is a common disorder of cardiac rhythm that is hereditary in a small subgroup of patients. It is characterized by disorganized atrial electrical activity and ineffective atrial contraction promoting blood stasis in the atria and reduces ventricular filling. It can result in palpitations, syncope, thromboembolic stroke, and congestive heart failure. Belongs to the potassium channel KCNE family.Protein type: Membrane protein, integralCellular Component: voltage-gated potassium channel complex; cell surface; membrane; lysosome; plasma membrane; integral to membraneMolecular Function: protein binding; voltage-gated potassium channel activity; protein homodimerization activity; potassium channel regulator activity; delayed rectifier potassium channel activity; cation channel activity; inward rectifier potassium channel activityBiological Process: tongue development; potassium ion import; aging |
| UniProt Protein Details: | |
| NCBI Summary: | small integral membrane subunit which binds with HERG, a pore-forming protein, to alter its channel function [RGD, Feb 2006] |
| UniProt Code: | P63161 |
| NCBI GenInfo Identifier: | 19424314 |
| NCBI Gene ID: | 171138 |
| NCBI Accession: | NP_598287.1 |
| UniProt Secondary Accession: | P63161,Q5FVT9, Q9WTW0 |
| UniProt Related Accession: | P63161 |
| Molecular Weight: | 14,356 Da |
| NCBI Full Name: | potassium voltage-gated channel subfamily E member 2 |
| NCBI Synonym Full Names: | potassium channel, voltage-gated Isk-related subfamily E regulatory beta subunit 2 |
| NCBI Official Symbol: | Kcne2Â Â |
| NCBI Official Synonym Symbols: | Mirp1Â Â |
| NCBI Protein Information: | potassium voltage-gated channel subfamily E member 2 |
| UniProt Protein Name: | Potassium voltage-gated channel subfamily E member 2 |
| UniProt Synonym Protein Names: | MinK-related peptide 1; Minimum potassium ion channel-related peptide 1; Potassium channel subunit beta MiRP1 |
| Protein Family: | Potassium voltage-gated channel subfamily |
| UniProt Gene Name: | Kcne2Â Â |
| UniProt Entry Name: | KCNE2_RAT |
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