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KCND2 Rabbit Polyclonal Antibody (CAB6203)

SKU:
CAB6203
Product Type:
Antibody
Reactivity:
Human
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Signal Transduction
  • Signal Transduction Antibodies 3 Anti-KCND2 Antibody CAB6203
  • Signal Transduction Antibodies 3 Anti-KCND2 Antibody CAB6203
€139 - €419
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Description

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KCND2 Rabbit Polyclonal Antibody (CAB6203)

The KCND2 Polyclonal Antibody (CAB6203) is a specialized tool for researchers studying KCND2, a potassium channel subunit that plays a key role in regulating neuronal excitability. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By targeting the KCND2 protein, this antibody allows for the precise detection and analysis of KCND2 expression in a variety of cell types, making it an invaluable resource for studies in neuroscience and neurology.KCND2, also known as Kv4.

2, is essential for controlling the firing patterns of neurons and has been implicated in various neurological disorders such as epilepsy and Parkinson's disease. Understanding the function of KCND2 is crucial for uncovering the underlying mechanisms of these conditions and developing targeted therapies. The KCND2 Polyclonal Antibody provides researchers with a powerful tool for investigating the role of KCND2 in neuronal excitability and neurological diseases, paving the way for advancements in the field of neuroscience.

Product Name:KCND2 Rabbit Polyclonal Antibody
SKU:CAB6203
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Mouse
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 501-630 of human KCND2 (NP_036413.1).
Sequence:ESCM EVAT VNRP SSHS PSLS SQQG VTST CCSR RHKK TFRI PNAN VSGS HQGS IQEL STIQ IRCV ERTP LSNS RSSL NAKM EECV KLNC EQPY VTTA IISI PTPP VTTP EGDD RPES PEYS GGNI VRVS AL
Tested Applications:WB ELISA
Recommended Dilution:WB,1:1000 - 1:5000
Synonyms:RK5; KV4.2; KCND2
Positive Sample:Mouse heart
Conjugate:Unconjugated
Cellular Localization:Cell junction, Cell membrane, Cell projection, Multi-pass membrane protein, Perikaryon, dendrite, dendritic spine, postsynaptic cell membrane, synapse.
Calculated MW:71kDa
Observed MW:70kDa

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shal-related subfamily, members of which form voltage-activated A-type potassium ion channels and are prominent in the repolarization phase of the action potential. This member mediates a rapidly inactivating, A-type outward potassium current which is not under the control of the N terminus as it is in Shaker channels.

Purification Method:Affinity purification
Gene ID:3751
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Product ImageWestern blot analysis of Mouse heart, using KCND2 antibody (CAB6203) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.

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