KCNC3 Antibody (PACO18132)
- SKU:
- PACO18132
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
KCNC3 Antibody (PACO18132)
The KCNC3 Polyclonal Antibody (PACO18132) is a high-quality antibody designed for researchers studying KCNC3, a potassium channel protein involved in neuronal function. This antibody, generated in rabbits, exhibits strong reactivity with human samples and is validated for use in Western blot applications. By targeting the KCNC3 protein, this antibody enables precise detection and analysis in various cell types, making it an essential tool for studies in neuroscience and neurodegenerative diseases.
KCNC3, also known as Kv3.3, plays a crucial role in regulating the firing of action potentials in neurons, impacting the overall excitability of the nervous system. Its involvement in neuronal processes makes it a key target for research into neurological disorders such as spinocerebellar ataxia type 13 (SCA13). Understanding the function of KCNC3 is fundamental for developing treatments that modulate neuronal activity and address conditions related to aberrant potassium channel function.
| Antibody Name: | KCNC3 Antibody (PACO18132) |
| Antibody SKU: | PACO18132 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:5000, WB:1:500-1:2000 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Synthetic peptide of human KCNC3 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: 293T cells, mouse brain tissue, Primary antibody: PACO18132(KCNC3 Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute. |
| Background: | The Shaker gene family of Drosophila encodes components of voltage-gated potassium channels and is comprised of four subfamilies. Based on sequence similarity, this gene is similar to one of these subfamilies, namely the Shaw subfamily. The protein encoded by this gene belongs to the delayed rectifier class of channel proteins and is an integral membrane protein that mediates the voltage-dependent potassium ion permeability of excitable membranes. |
| Synonyms: | potassium voltage-gated channel, Shaw-related subfamily, member 3 |
| UniProt Protein Function: | Kv3.3: This protein mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Defects in KCNC3 are the cause of spinocerebellar ataxia type 13 (SCA13). Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA13 is an autosomal dominant cerebellar ataxia (ADCA) characterized by slow progression and variable age at onset, ranging from childhood to late adulthood. Mental retardation can be present in some patients. Belongs to the potassium channel family. C (Shaw) (TC 1.A.1.2) subfamily. Kv3.3/KCNC3 sub-subfamily. |
| UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Membrane protein, integral Chromosomal Location of Human Ortholog: 19q13.33 Cellular Component: plasma membrane; voltage-gated potassium channel complex Molecular Function:delayed rectifier potassium channel activity; voltage-gated potassium channel activity Biological Process: protein tetramerization Disease: Spinocerebellar Ataxia 13 |
| NCBI Summary: | The Shaker gene family of Drosophila encodes components of voltage-gated potassium channels and is comprised of four subfamilies. Based on sequence similarity, this gene is similar to one of these subfamilies, namely the Shaw subfamily. The protein encoded by this gene belongs to the delayed rectifier class of channel proteins and is an integral membrane protein that mediates the voltage-dependent potassium ion permeability of excitable membranes. Alternate splicing results in several transcript variants. [provided by RefSeq, Mar 2014] |
| UniProt Code: | Q14003 |
| NCBI GenInfo Identifier: | 212276500 |
| NCBI Gene ID: | 3748 |
| NCBI Accession: | Q14003.3 |
| UniProt Related Accession: | Q14003 |
| Molecular Weight: | 80,578 Da |
| NCBI Full Name: | Potassium voltage-gated channel subfamily C member 3 |
| NCBI Synonym Full Names: | potassium voltage-gated channel subfamily C member 3 |
| NCBI Official Symbol: | KCNC3Â Â |
| NCBI Official Synonym Symbols: | KV3.3; SCA13; KSHIIIDÂ Â |
| NCBI Protein Information: | potassium voltage-gated channel subfamily C member 3 |
| UniProt Protein Name: | Potassium voltage-gated channel subfamily C member 3 |
| UniProt Synonym Protein Names: | KSHIIID; Voltage-gated potassium channel subunit Kv3.3 |
| Protein Family: | Potassium voltage-gated channel subfamily |
| UniProt Gene Name: | KCNC3Â Â |
| UniProt Entry Name: | KCNC3_HUMAN |
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