| UniProt Protein Function: | KCNC2: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Channel properties are modulated by subunit assembly. Belongs to the potassium channel family. C (Shaw) (TC 1.A.1.2) subfamily. Kv3.2/KCNC2 sub-subfamily. 4 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 12q14.1 Cellular Component: voltage-gated potassium channel complex; integral to membrane; plasma membrane Molecular Function:delayed rectifier potassium channel activity Biological Process: synaptic transmission; regulation of action potential; energy reserve metabolic process; regulation of insulin secretion; protein homooligomerization |
| NCBI Summary: | The Shaker gene family of Drosophila encodes components of voltage-gated potassium channels and is comprised of four subfamilies. Based on sequence similarity, this gene is similar to one of these subfamilies, namely the Shaw subfamily. The protein encoded by this gene belongs to the delayed rectifier class of channel proteins and is an integral membrane protein that mediates the voltage-dependent potassium ion permeability of excitable membranes. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012] |
| UniProt Code: | Q96PR1 |
| NCBI GenInfo Identifier: | 74752079 |
| NCBI Gene ID: | 3747 |
| NCBI Accession: | Q96PR1.1 |
| UniProt Secondary Accession: | Q96PR1,Q4LE77, Q86W09, Q8N1V9, Q96PR0, B7Z231, F5H030 J3KPP5, |
| UniProt Related Accession: | Q96PR1 |
| Molecular Weight: | 638 |
| NCBI Full Name: | Potassium voltage-gated channel subfamily C member 2 |
| NCBI Synonym Full Names: | potassium voltage-gated channel, Shaw-related subfamily, member 2 |
| NCBI Official Symbol: | KCNC2Â Â |
| NCBI Official Synonym Symbols: | KV3.2Â Â |
| NCBI Protein Information: | potassium voltage-gated channel subfamily C member 2; voltage-gated potassium channel Kv3.2 |
| UniProt Protein Name: | Potassium voltage-gated channel subfamily C member 2 |
| UniProt Synonym Protein Names: | Voltage-gated potassium channel Kv3.2 |
| Protein Family: | Potassium voltage-gated channel subfamily |
| UniProt Gene Name: | KCNC2Â Â |
| UniProt Entry Name: | KCNC2_HUMAN |
