The KCNC2 Antibody (PAC018131) is a valuable tool for researchers studying KCNC2, a potassium channel subunit involved in neuronal function and excitability. This polyclonal antibody, produced in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By binding to the KCNC2 protein, this antibody allows for the detection and analysis of KCNC2 in various cell types, making it an ideal choice for studies in neuroscience and neurology.KCNC2, also known as Kv3.2, plays a crucial role in regulating neuronal firing and action potential repolarization.
Dysregulation of KCNC2 has been implicated in neurological disorders such as epilepsy and ataxia, making it a promising target for research into these conditions. Understanding the function of KCNC2 is essential for developing treatments that target potassium channels and neuronal excitability in the context of neurological diseases.Overall, the KCNC2 Antibody offers researchers a reliable tool for investigating the role of KCNC2 in neuronal function and pathology, providing valuable insights into the mechanisms underlying neurological disorders and potential therapeutic strategies.
Antibody Name:
KCNC2 Antibody (PACO18131)
Antibody SKU:
PACO18131
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:1000-1:2000, IHC:1:150-1:500
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Synthetic peptide of human KCNC2
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO18131(KCNC2 Antibody) at dilution 1/100, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO18131(KCNC2 Antibody) at dilution 1/100, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
The Shaker gene family of Drosophila encodes components of voltage-gated potassium channels and is comprised of four subfamilies. Based on sequence similarity, this gene is similar to one of these subfamilies, namely the Shaw subfamily. The protein encoded by this gene belongs to the delayed rectifier class of channel proteins and is an integral membrane protein that mediates the voltage-dependent potassium ion permeability of excitable membranes. Several transcript variants encoding different isoforms have been found for this gene.
Synonyms:
potassium voltage-gated channel, Shaw-related subfamily, member 2
UniProt Protein Function:
KCNC2: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Channel properties are modulated by subunit assembly. Belongs to the potassium channel family. C (Shaw) (TC 1.A.1.2) subfamily. Kv3.2/KCNC2 sub-subfamily. 4 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:
Protein type:Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 12q14.1
Cellular Component: voltage-gated potassium channel complex; integral to membrane; plasma membrane
Biological Process: synaptic transmission; regulation of action potential; energy reserve metabolic process; regulation of insulin secretion; protein homooligomerization
NCBI Summary:
The Shaker gene family of Drosophila encodes components of voltage-gated potassium channels and is comprised of four subfamilies. Based on sequence similarity, this gene is similar to one of these subfamilies, namely the Shaw subfamily. The protein encoded by this gene belongs to the delayed rectifier class of channel proteins and is an integral membrane protein that mediates the voltage-dependent potassium ion permeability of excitable membranes. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]
