The KCNC2 Antibody (PAC018130) is a polyclonal antibody designed for research involving KCNC2, a protein that plays a crucial role in regulating neuronal excitability and action potential duration. This antibody, raised in rabbits, is highly specific and reactive with human samples, making it a valuable tool for studying the function and localization of KCNC2 in various cell types.KCNC2, also known as Kv3.2, is a voltage-gated potassium channel that is essential for controlling the firing patterns of neurons in the central nervous system. Dysregulation of KCNC2 has been implicated in neurological disorders such as epilepsy, ataxia, and schizophrenia, making it a promising therapeutic target for drug development.
The KCNC2 Antibody (PAC018130) is validated for use in Western blot applications, enabling researchers to detect and analyze KCNC2 protein expression levels in different tissues and cell lines. By understanding the role of KCNC2 in neural function and dysfunction, researchers can uncover new insights into brain disorders and potentially identify novel treatment strategies.
Antibody Name:
KCNC2 Antibody (PACO18130)
Antibody SKU:
PACO18130
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:1000-1:5000, WB:1:200-1:1000
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Synthetic peptide of human KCNC2
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Gel: 8%SDS-PAGE, Lysate: 50 μg, Lane 1-2: 231 cells, human brain malignant glioma tissue, Primary antibody: PACO18130(KCNC2 Antibody) at dilution 1/450, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds.
Background:
The Shaker gene family of Drosophila encodes components of voltage-gated potassium channels and is comprised of four subfamilies. Based on sequence similarity, this gene is similar to one of these subfamilies, namely the Shaw subfamily. The protein encoded by this gene belongs to the delayed rectifier class of channel proteins and is an integral membrane protein that mediates the voltage-dependent potassium ion permeability of excitable membranes. Several transcript variants encoding different isoforms have been found for this gene.
Synonyms:
potassium voltage-gated channel, Shaw-related subfamily, member 2
UniProt Protein Function:
KCNC2: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Channel properties are modulated by subunit assembly. Belongs to the potassium channel family. C (Shaw) (TC 1.A.1.2) subfamily. Kv3.2/KCNC2 sub-subfamily. 4 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:
Protein type:Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 12q14.1
Cellular Component: voltage-gated potassium channel complex; integral to membrane; plasma membrane
Biological Process: synaptic transmission; regulation of action potential; energy reserve metabolic process; regulation of insulin secretion; protein homooligomerization
NCBI Summary:
The Shaker gene family of Drosophila encodes components of voltage-gated potassium channels and is comprised of four subfamilies. Based on sequence similarity, this gene is similar to one of these subfamilies, namely the Shaw subfamily. The protein encoded by this gene belongs to the delayed rectifier class of channel proteins and is an integral membrane protein that mediates the voltage-dependent potassium ion permeability of excitable membranes. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]
