KCNC2 Antibody (PACO01007)
- SKU:
- PACO01007
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
KCNC2 Antibody (PACO01007)
The KCNC2 Polyclonal Antibody (PACO01007) is a valuable tool for researchers studying the potassium voltage-gated channel subfamily C member 2 (KCNC2). This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the KCNC2 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it an ideal choice for studies in neurobiology and neurological disorders.KCNC2 is a crucial component of voltage-gated potassium channels in the brain, playing a key role in regulating neuronal excitability and action potential firing.
Dysregulation of KCNC2 has been linked to conditions such as epilepsy, ataxia, and neurodegenerative diseases, making it a promising target for therapeutic interventions. Investigating the function of KCNC2 is essential for advancing our understanding of these neurological disorders and developing novel treatment strategies.Overall, the KCNC2 Polyclonal Antibody offers researchers a reliable tool for exploring the role of KCNC2 in brain function and dysfunction, paving the way for advancements in neuroscience and the development of potential therapies for neurological conditions.
| Antibody Name: | KCNC2 Antibody |
| Antibody SKU: | PACO01007 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | WB:1:500-1:2000, IHC:1:100-1:300 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | synthesized peptide derived from the C-terminal region of human KV3.2. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | KCNC2; Potassium voltage-gated channel subfamily C member 2; Voltage-gated potassium channel Kv3.2 |
| UniProt Protein Function: | KCNC2: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Channel properties are modulated by subunit assembly. Belongs to the potassium channel family. C (Shaw) (TC 1.A.1.2) subfamily. Kv3.2/KCNC2 sub-subfamily. 4 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 12q14.1 Cellular Component: voltage-gated potassium channel complex; integral to membrane; plasma membrane Molecular Function:delayed rectifier potassium channel activity Biological Process: synaptic transmission; regulation of action potential; energy reserve metabolic process; regulation of insulin secretion; protein homooligomerization |
| NCBI Summary: | The Shaker gene family of Drosophila encodes components of voltage-gated potassium channels and is comprised of four subfamilies. Based on sequence similarity, this gene is similar to one of these subfamilies, namely the Shaw subfamily. The protein encoded by this gene belongs to the delayed rectifier class of channel proteins and is an integral membrane protein that mediates the voltage-dependent potassium ion permeability of excitable membranes. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012] |
| UniProt Code: | Q96PR1 |
| NCBI GenInfo Identifier: | 74752079 |
| NCBI Gene ID: | 3747 |
| NCBI Accession: | Q96PR1.1 |
| UniProt Secondary Accession: | Q96PR1,Q4LE77, Q86W09, Q8N1V9, Q96PR0, B7Z231, F5H030 J3KPP5, |
| UniProt Related Accession: | Q96PR1 |
| Molecular Weight: | 638 |
| NCBI Full Name: | Potassium voltage-gated channel subfamily C member 2 |
| NCBI Synonym Full Names: | potassium voltage-gated channel, Shaw-related subfamily, member 2 |
| NCBI Official Symbol: | KCNC2Â Â |
| NCBI Official Synonym Symbols: | KV3.2Â Â |
| NCBI Protein Information: | potassium voltage-gated channel subfamily C member 2; voltage-gated potassium channel Kv3.2 |
| UniProt Protein Name: | Potassium voltage-gated channel subfamily C member 2 |
| UniProt Synonym Protein Names: | Voltage-gated potassium channel Kv3.2 |
| Protein Family: | Potassium voltage-gated channel subfamily |
| UniProt Gene Name: | KCNC2Â Â |
| UniProt Entry Name: | KCNC2_HUMAN |
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