KCNB1 Antibody (PACO19584)
- SKU:
- PACO19584
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Frequently bought together:
Description
KCNB1 Antibody (PACO19584)
The KCNB1 Polyclonal Antibody (PACO19584) is a valuable tool for researchers studying the KCNB1 protein, a voltage-gated potassium channel involved in regulating cell excitability and neurotransmission. This antibody, generated in rabbits, is highly specific to human samples and has been validated for use in Western blotting applications.By binding to the KCNB1 protein, this antibody allows for the detection and analysis of KCNB1 expression in various cell types, making it ideal for studies in neuroscience and neurobiology. The KCNB1 protein plays a crucial role in neuronal signaling and has been implicated in conditions such as epilepsy and neurodegenerative diseases.
Understanding the function and regulation of KCNB1 is essential for developing targeted treatments for these disorders.Overall, the KCNB1 Polyclonal Antibody (PACO19584) is a reliable tool for researchers investigating the role of KCNB1 in neurological disorders and other related fields. Its high specificity and sensitivity make it a valuable asset for furthering our understanding of the molecular mechanisms underlying neurophysiology.
| Antibody Name: | KCNB1 Antibody (PACO19584) |
| Antibody SKU: | PACO19584 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:1000-1:2000, IHC:1:25-1:100 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Synthetic peptide of human KCNB1 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO19584(KCNB1 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200). |
 | The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO19584(KCNB1 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200). |
| Background: | Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shab-related subfamily. This member is a delayed rectifier potassium channel and its activity is modulated by some other family members. |
| Synonyms: | potassium voltage-gated channel, Shab-related subfamily, member 1 |
| UniProt Protein Function: | Kv2.1: a potassium voltage-gated channel protein of subfamily B. Mediates the voltage-dependent potassium ion permeability of excitable membranes. Channels open or close in response to the voltage difference across the membrane, letting K ions pass in accordance with their electrochemical gradient.Protein type: Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass; Channel, cation; Channel, ligand-gatedChromosomal Location of Human Ortholog: 20q13.2Cellular Component: postsynaptic membrane; voltage-gated potassium channel complex; dendrite; plasma membrane; integral to membraneMolecular Function: protein binding; outward rectifier potassium channel activity; delayed rectifier potassium channel activity; protein N-terminus bindingBiological Process: synaptic transmission; energy reserve metabolic process; regulation of insulin secretion; protein homooligomerizationDisease: Epileptic Encephalopathy, Early Infantile, 26 |
| UniProt Protein Details: | |
| NCBI Summary: | Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shab-related subfamily. This member is a delayed rectifier potassium channel and its activity is modulated by some other family members. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q14721 |
| NCBI GenInfo Identifier: | 24418854 |
| NCBI Gene ID: | 3745 |
| NCBI Accession: | Q14721.2 |
| UniProt Secondary Accession: | Q14721,Q14193 |
| UniProt Related Accession: | Q14721 |
| Molecular Weight: | 95,878 Da |
| NCBI Full Name: | Potassium voltage-gated channel subfamily B member 1 |
| NCBI Synonym Full Names: | potassium voltage-gated channel, Shab-related subfamily, member 1 |
| NCBI Official Symbol: | KCNB1Â Â |
| NCBI Official Synonym Symbols: | DRK1; KV2.1; EIEE26; h-DRK1Â Â |
| NCBI Protein Information: | potassium voltage-gated channel subfamily B member 1; h-DRK1 K(+) channel; potassium channel protein DRK1; delayed rectifier potassium channel 1; delayed rectifier potassium channel Kv2.1; voltage-gated potassium channel subunit Kv2.1 |
| UniProt Protein Name: | Potassium voltage-gated channel subfamily B member 1 |
| UniProt Synonym Protein Names: | Delayed rectifier potassium channel 1; DRK1; h-DRK1; Voltage-gated potassium channel subunit Kv2.1 |
| Protein Family: | Potassium voltage-gated channel subfamily |
| UniProt Gene Name: | KCNB1Â Â |
| UniProt Entry Name: | KCNB1_HUMAN |
| Antibodies |
| Phospho-KCNB1 (S805) Antibody (PACO05959) |
| Phospho-KCNB1 (S567) Antibody (PACO05960) |
| KCNB1 Antibody (PACO05961) |
| KCNB1 Antibody (PACO05962) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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