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KCNB1 Antibody (PACO05962)

SKU:
PACO05962
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
$323
Frequently bought together:

Description

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KCNB1 Antibody (PACO05962)

The KCNB1 Antibody (PACO05962) is a valuable tool for researchers studying the KCNB1 protein, a voltage-gated potassium channel that plays a critical role in regulating neuronal excitability. This polyclonal antibody, raised in rabbits, is highly specific to human samples and has been validated for use in Western blot applications.The KCNB1 Antibody binds specifically to the KCNB1 protein, allowing for accurate detection and analysis in various cell types. Its high reactivity and specificity make it ideal for studies in neuroscience and neurology, as well as in research on neurodegenerative diseases like Alzheimer's and Parkinson's.

Understanding the function of the KCNB1 protein is essential for unraveling the mechanisms underlying neuronal excitability and communication in the brain. The KCNB1 Antibody provides researchers with a reliable tool for investigating the role of this important potassium channel in health and disease, potentially leading to new insights and therapeutic strategies for neurological disorders.

Antibody Name:KCNB1 Antibody (PACO05962)
Antibody SKU:PACO05962
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, WB
Recommended Dilutions:ELISA:1:20000, WB:1:500-1:2000
Species Reactivity:Human, Mouse, Rat
Immunogen:Synthesized peptide derived from human KV2.1 around the non-phosphorylation site of S805.
Form:Liquid
Storage Buffer:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:KCNB1; Potassium voltage-gated channel subfamily B member 1; Delayed rectifier potassium channel 1; DRK1; h-DRK1; Voltage-gated potassium channel subunit Kv2.1
UniProt Protein Function:Kv2.1: a potassium voltage-gated channel protein of subfamily B. Mediates the voltage-dependent potassium ion permeability of excitable membranes. Channels open or close in response to the voltage difference across the membrane, letting K ions pass in accordance with their electrochemical gradient.Protein type: Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass; Channel, cation; Channel, ligand-gatedChromosomal Location of Human Ortholog: 20q13.2Cellular Component: postsynaptic membrane; voltage-gated potassium channel complex; dendrite; plasma membrane; integral to membraneMolecular Function: protein binding; outward rectifier potassium channel activity; delayed rectifier potassium channel activity; protein N-terminus bindingBiological Process: synaptic transmission; energy reserve metabolic process; regulation of insulin secretion; protein homooligomerizationDisease: Epileptic Encephalopathy, Early Infantile, 26
UniProt Protein Details:
NCBI Summary:Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shab-related subfamily. This member is a delayed rectifier potassium channel and its activity is modulated by some other family members. [provided by RefSeq, Jul 2008]
UniProt Code:Q14721
NCBI GenInfo Identifier:24418854
NCBI Gene ID:3745
NCBI Accession:Q14721.2
UniProt Secondary Accession:Q14721,Q14193
UniProt Related Accession:Q14721
Molecular Weight:95,878 Da
NCBI Full Name:Potassium voltage-gated channel subfamily B member 1
NCBI Synonym Full Names:potassium voltage-gated channel, Shab-related subfamily, member 1
NCBI Official Symbol:KCNB1  
NCBI Official Synonym Symbols:DRK1; KV2.1; EIEE26; h-DRK1  
NCBI Protein Information:potassium voltage-gated channel subfamily B member 1; h-DRK1 K(+) channel; potassium channel protein DRK1; delayed rectifier potassium channel 1; delayed rectifier potassium channel Kv2.1; voltage-gated potassium channel subunit Kv2.1
UniProt Protein Name:Potassium voltage-gated channel subfamily B member 1
UniProt Synonym Protein Names:Delayed rectifier potassium channel 1; DRK1; h-DRK1; Voltage-gated potassium channel subunit Kv2.1
Protein Family:Potassium voltage-gated channel subfamily
UniProt Gene Name:KCNB1  
UniProt Entry Name:KCNB1_HUMAN

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