The KCNB1 Polyclonal Antibody (PACO05961) is a valuable tool for researchers studying the KCNB1 protein, a voltage-gated potassium channel critical for regulating neuronal excitability. This antibody, produced in rabbits, is highly specific for human samples and has been validated for use in Western blotting applications. By binding to the KCNB1 protein, this antibody allows for precise detection and analysis in various cell types, making it an essential component for neuroscience and neurology research.KCNB1, also known as the Kv2.1 channel, plays a crucial role in controlling action potential repolarization and shaping neuronal firing patterns.
Dysfunction of KCNB1 has been linked to several neurological disorders, including epilepsy, schizophrenia, and Alzheimer's disease. By studying the function of KCNB1, researchers can gain valuable insights into these conditions and potentially develop new therapeutic strategies targeting the potassium channel.Overall, the KCNB1 Polyclonal Antibody is a versatile tool for investigating the role of KCNB1 in neuronal function and neurological disorders, contributing to advancements in neuroscience research and potential clinical applications in the future.
Antibody Name:
KCNB1 Antibody (PACO05961)
Antibody SKU:
PACO05961
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC, IF
Recommended Dilutions:
ELISA:1:20000, IHC:1:100-1:300, IF:1:200-1:1000
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Synthesized peptide derived from human Kv2.1 around the non-phosphorylation site of S567.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
KCNB1; Potassium voltage-gated channel subfamily B member 1; Delayed rectifier potassium channel 1; DRK1; h-DRK1; Voltage-gated potassium channel subunit Kv2.1
UniProt Protein Function:
Kv2.1: a potassium voltage-gated channel protein of subfamily B. Mediates the voltage-dependent potassium ion permeability of excitable membranes. Channels open or close in response to the voltage difference across the membrane, letting K ions pass in accordance with their electrochemical gradient.Protein type: Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass; Channel, cation; Channel, ligand-gatedChromosomal Location of Human Ortholog: 20q13.2Cellular Component: postsynaptic membrane; voltage-gated potassium channel complex; dendrite; plasma membrane; integral to membraneMolecular Function: protein binding; outward rectifier potassium channel activity; delayed rectifier potassium channel activity; protein N-terminus bindingBiological Process: synaptic transmission; energy reserve metabolic process; regulation of insulin secretion; protein homooligomerizationDisease: Epileptic Encephalopathy, Early Infantile, 26
UniProt Protein Details:
NCBI Summary:
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shab-related subfamily. This member is a delayed rectifier potassium channel and its activity is modulated by some other family members. [provided by RefSeq, Jul 2008]
