KCNA7 Antibody (PACO19874)
- SKU:
- PACO19874
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
KCNA7 Antibody (PACO19874)
The KCNA7 Polyclonal Antibody (PACO19874) is a key tool for researchers studying the KCNA7 protein, a member of the voltage-gated potassium channel family involved in regulating the electrical activity of cells. This antibody, produced in rabbits, is highly specific for human KCNA7 samples and has been validated for use in Western blot applications.By targeting the KCNA7 protein, this antibody enables researchers to detect and analyze its expression in various cell types, making it an essential tool for studies in neuroscience, cardiology, and other fields where potassium channels are known to play a crucial role.
Understanding the function of KCNA7 is vital for advancements in drug development, particularly for conditions related to abnormal electrical signaling in the body.Overall, the KCNA7 Polyclonal Antibody (PACO19874) provides researchers with a reliable tool to explore the functions and potential therapeutic applications of the KCNA7 protein in various physiological and pathological contexts.
| Antibody Name: | KCNA7 Antibody (PACO19874) |
| Antibody SKU: | PACO19874 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:2000, IHC:1:50-1:200 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Synthetic peptide of human KCNA7 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO19874(KCNA7 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200). |
 | Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Hela cells, mouse kidney tissue, Primary antibody: PACO19874(KCNA7 Antibody) at dilution 1/550, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 40 seconds. |
 | The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO19874(KCNA7 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200). |
| Background: | Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. |
| Synonyms: | potassium voltage-gated channel, shaker-related subfamily, member 7 |
| UniProt Protein Function: | Kv1.7: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.7/KCNA7 sub-subfamily.Protein type: Membrane protein, multi-passChromosomal Location of Human Ortholog: 19q13.3Cellular Component: voltage-gated potassium channel complex; integral to membrane; plasma membraneMolecular Function: delayed rectifier potassium channel activityBiological Process: synaptic transmission; protein homooligomerization |
| UniProt Protein Details: | |
| NCBI Summary: | Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. The gene is expressed preferentially in skeletal muscle, heart and kidney. It is a candidate gene for inherited cardiac disorders. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q96RP8 |
| NCBI GenInfo Identifier: | 25952092 |
| NCBI Gene ID: | 3743 |
| NCBI Accession: | NP_114092.2 |
| UniProt Secondary Accession: | Q96RP8,Q9BYS4, A1KYX7 |
| UniProt Related Accession: | Q96RP8 |
| Molecular Weight: | 50,559 Da |
| NCBI Full Name: | potassium voltage-gated channel subfamily A member 7 |
| NCBI Synonym Full Names: | potassium channel, voltage gated shaker related subfamily A, member 7 |
| NCBI Official Symbol: | KCNA7Â Â |
| NCBI Official Synonym Symbols: | HAK6; KV1.7Â Â |
| NCBI Protein Information: | potassium voltage-gated channel subfamily A member 7 |
| UniProt Protein Name: | Potassium voltage-gated channel subfamily A member 7 |
| UniProt Synonym Protein Names: | Voltage-gated potassium channel subunit Kv1.7 |
| Protein Family: | Potassium voltage-gated channel subfamily |
| UniProt Gene Name: | KCNA7Â Â |
| UniProt Entry Name: | KCNA7_HUMAN |
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