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KCNA6 Antibody (PACO27737)

SKU:
PACO27737
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
IHC
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
  • KCNA6 Antibody PACO27737
  • KCNA6 Antibody PACO27737
€359

Description

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KCNA6 Antibody (PACO27737)

The KCNA6 Polyclonal Antibody (PACO27737) is a vital tool for researchers studying the voltage-gated potassium channel Kv1.6, encoded by the KCNA6 gene. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the KCNA6 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it an excellent choice for investigations in neuroscience, cardiovascular research, and beyond.

Kv1.6 plays a crucial role in regulating neuronal excitability and is implicated in various neurological disorders such as epilepsy and multiple sclerosis. Research into the function and regulation of KCNA6 is essential for gaining a deeper understanding of these conditions and potentially developing new treatments. The KCNA6 Polyclonal Antibody offers researchers a reliable tool for uncovering the mysteries of this important potassium channel, contributing to advancements in the field of neurobiology and beyond.

Antibody Name:KCNA6 Antibody (PACO27737)
Antibody SKU:PACO27737
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, IHC
Recommended Dilutions:ELISA:1:2000-1:10000, IHC:1:20-1:200
Species Reactivity:Human
Immunogen:Recombinant Human Potassium voltage-gated channel subfamily A member 6 protein (1-171AA)
Form:Liquid
Storage Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method:>95%, Protein G purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Product ImageImmunohistochemistry of paraffin-embedded human breast cancer using PACO27737 at dilution of 1:100.
Product ImageImmunohistochemistry of paraffin-embedded human liver cancer using PACO27737 at dilution of 1:100.
Background:Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient (PubMed:2347305, PubMed:14575698). The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed:2347305, PubMed:14575698). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA6, and possibly other family members as well; channel properties depend on the type of α subunits that are part of the channel. Channel properties are modulated by cytoplasmic β subunits that regulate the subcellular location of the α subunits and promote rapid inactivation. Homotetrameric channels display rapid activation and slow inactivation (PubMed:2347305).
Synonyms:Potassium voltage-gated channel subfamily A member 6 (Voltage-gated potassium channel HBK2) (Voltage-gated potassium channel subunit Kv1.6), KCNA6
UniProt Protein Function:Kv1.6: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.6/KCNA6 sub-subfamily.Protein type: Membrane protein, integral; Membrane protein, multi-passChromosomal Location of Human Ortholog: 12p13Cellular Component: voltage-gated potassium channel complex; integral to plasma membrane; plasma membrane; integral to membraneMolecular Function: voltage-gated potassium channel activity; delayed rectifier potassium channel activityBiological Process: synaptic transmission; protein homooligomerization; potassium ion transport
UniProt Protein Details:
NCBI Summary:Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class. The coding region of this gene is intronless, and the gene is clustered with genes KCNA1 and KCNA5 on chromosome 12. [provided by RefSeq, Jul 2008]
UniProt Code:P17658
NCBI GenInfo Identifier:116434
NCBI Gene ID:3742
NCBI Accession:P17658.1
UniProt Secondary Accession:P17658
UniProt Related Accession:P17658
Molecular Weight:
NCBI Full Name:Potassium voltage-gated channel subfamily A member 6
NCBI Synonym Full Names:potassium voltage-gated channel subfamily A member 6
NCBI Official Symbol:KCNA6  
NCBI Official Synonym Symbols:HBK2; KV1.6; PPP1R96  
NCBI Protein Information:potassium voltage-gated channel subfamily A member 6
UniProt Protein Name:Potassium voltage-gated channel subfamily A member 6
UniProt Synonym Protein Names:Voltage-gated potassium channel HBK2; Voltage-gated potassium channel subunit Kv1.6
Protein Family:Potassium voltage-gated channel subfamily
UniProt Gene Name:KCNA6  
UniProt Entry Name:KCNA6_HUMAN
Secondary Antibody
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