KCNA3 Polyclonal Antibody
- SKU:
- CAB8126
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Description
Product Name: | KCNA3 Polyclonal Antibody |
Product Code: | CAB8126 |
Reactivity: | Human, Mouse |
Applications: | Western blotting |
Host Species: | Rabbit |
Purification Method: | Affinity purification |
Isotype: | IgG |
Reactivity: | Human, Mouse |
Tested Applications: | WB, ELISA |
Key Applications: | Western blotting |
Recommended Dilution: | WB 1:500-1:2000 |
Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Cellular Location: | Cell membrane, Multi-pass membrane protein |
Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, members of which allow nerve cells to efficiently repolarize following an action potential. It plays an essential role in T-cell proliferation and activation. This gene appears to be intronless and it is clustered together with KCNA2 and KCNA10 genes on chromosome 1.
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 486-575 of human KCNA3 (NP_002223.3). |
Sequence: | FYHRE TEGEE QSQYM HVGSC QHLSS SAEEL RKARS NSTLS KSEYM VIEEG GMNHS AFPQT PFKTG NSTAT CTTNN NPNSC VNIKK IFTDV |
Synonyms: | MK3, HGK5, HLK3, PCN3, HPCN3, KV1.3, HUKIII |
Calculated MW: | 64kDa |
Observed MW: | Refer to figures |