The KCNA2 Polyclonal Antibody (CAB6295) is a valuable tool for researchers studying the KCNA2 protein, a voltage-gated potassium channel essential for regulating neuronal excitability. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the KCNA2 protein, researchers can effectively detect and analyze its expression in various cell types, making it a versatile tool for neurological research.KCNA2, also known as Kv1.2, plays a crucial role in controlling action potential duration and membrane potential in neurons, making it a key player in neuronal function and synaptic transmission.
Dysregulation of KCNA2 has been implicated in neurological disorders such as epilepsy, ataxia, and neurodegenerative diseases, highlighting its importance in understanding and potentially treating these conditions. By studying the activity of KCNA2, researchers can gain valuable insights into the mechanisms underlying these disorders and develop targeted therapies that modulate potassium channel function.
Product Name:
KCNA2 Rabbit Polyclonal Antibody
SKU:
CAB6295
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-165 of human KCNA2 (NP_004965.1).
Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, members of which allow nerve cells to efficiently repolarize following an action potential. The coding region of this gene is intronless, and the gene is clustered with genes KCNA3 and KCNA10 on chromosome 1.
Purification Method:
Affinity purification
Gene ID:
3737
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of mouse plasma, using KCNA2 antibody (CAB6295) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
