KCNA1 Rabbit Polyclonal Antibody (CAB16906)
- SKU:
- CAB16906
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Frequently bought together:
Description
Product Name: | KCNA1 Rabbit Polyclonal Antibody |
SKU: | CAB16906 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 426-495 of human KCNA1 (NP_000208.2). |
Sequence: | QLLH VSSP NLAS DSDL SRRS SSTM SKSE YMEI EEDM NNSI AHYR QVNI RTAN CTTA NQNC VNKS KLLT DV |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IF/ICC,1:50 - 1:200 |
Synonyms: | EA1; MK1; AEMK; HBK1; HUK1; MBK1; RBK1; KV1.1; KCNA1 |
Positive Sample: | HeLa,Mouse brain,Mouse spinal cord,Rat brain |
Cellular Localization: | Cell junction, Cell membrane, Cell projection, Cytoplasmic vesicle, Endoplasmic reticulum, Membrane, Multi-pass membrane protein, Perikaryon, axon, dendrite, presynaptic cell membrane, synapse. |
Calculated MW: | 56kDa |
Observed MW: | 60kDa/75kDa |
This gene encodes a voltage-gated delayed potassium channel that is phylogenetically related to the Drosophila Shaker channel. The encoded protein has six putative transmembrane segments (S1-S6), and the loop between S5 and S6 forms the pore and contains the conserved selectivity filter motif (GYGD). The functional channel is a homotetramer. The N-terminus of the channel is associated with beta subunits that can modify the inactivation properties of the channel as well as affect expression levels. The C-terminus of the channel is complexed to a PDZ domain protein that is responsible for channel targeting. Mutations in this gene have been associated with myokymia with periodic ataxia (AEMK).
Purification Method: | Affinity purification |
Gene ID: | 3736 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |