The KBTBD7 Polyclonal Antibody (CAB7392) is a valuable tool for researchers studying the KBTBD7 protein, a substrate-specific adaptor of the Cullin-3 (Cul3) E3 ubiquitin-protein ligase complex. This antibody, produced in rabbits, has high reactivity with human samples and has been verified for use in Western blot applications. By binding to the KBTBD7 protein, this antibody allows for the detection and analysis of KBTBD7 expression in a variety of cell types, making it well-suited for investigations in the fields of cell biology and molecular biology.KBTBD7 is known to play a crucial role in the ubiquitination and subsequent degradation of specific target proteins, thereby regulating various cellular processes such as cell cycle progression, signal transduction, and gene expression.
Dysfunction of KBTBD7 has been implicated in the development and progression of certain diseases, including cancer and neurodevelopmental disorders. Therefore, studying the function and regulation of KBTBD7 with the help of this polyclonal antibody may provide important insights for the development of targeted therapies and diagnostic tools in the future.
Product Name:
KBTBD7 Rabbit Polyclonal Antibody
SKU:
CAB7392
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 475-684 of human KBTBD7 (NP_115514.2).
The protein encoded by this gene is a transcriptional activator, having been shown to increase the transcription of activator protein-1 and serum response element. The encoded protein can also form a complex with KBTBD6 and CUL3, which regulates the ubiquitylation and degradation of TIAM1, which is a regulator of RAC1.
Purification Method:
Affinity purification
Gene ID:
84078
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using KBTBD7 antibody (CAB7392) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 90s.
