The KATNAL2 Polyclonal Antibody (PAC037634) is a vital tool for researchers studying the Katanin-like 2 (KATNAL2) protein, which is involved in microtubule severing and regulation of cell division. This antibody, produced in rabbits, shows high specificity and sensitivity towards human samples, making it ideal for use in Western blot applications.KATNAL2 is known for its crucial role in controlling microtubule dynamics during cell division, making it essential for processes such as mitosis and meiosis. Dysregulation of KATNAL2 has been linked to various diseases, including cancer and neurodevelopmental disorders.
By using the PAC037634 antibody, researchers can accurately detect and analyze KATNAL2 expression in different cell types, providing valuable insights into its functions and potential therapeutic targets.Furthermore, understanding the mechanisms of KATNAL2 could lead to the development of novel treatment strategies for diseases characterized by abnormal cell division and microtubule dynamics. By utilizing the PAC037634 antibody, researchers can further explore the role of KATNAL2 in both normal cellular processes and pathological conditions, advancing our knowledge of this critical protein.
Western blot. All lanes: KATNAL2 antibody at 1µg/ml + U251 whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 62, 53 kDa. Observed band size: 62 kDa.
Immunohistochemistry of paraffin-embedded human breast cancer using PACO37634 at dilution of 1:100.
Background:
Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays.
KATNAL2: Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays. Belongs to the AAA ATPase family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: EC 3.6.4.3; HydrolaseChromosomal Location of Human Ortholog: 18q21.1Cellular Component: microtubule; cytoplasm; nucleusMolecular Function: microtubule binding; microtubule-severing ATPase activity; ATP bindingBiological Process: metabolic process; microtubule severing; cytoplasmic microtubule organization and biogenesis
