The KAT6A Polyclonal Antibody (CAB15006) is a valuable tool for researchers studying KAT6A, a histone acetyltransferase involved in gene regulation and chromatin remodeling. This antibody, derived from rabbit serum, is highly specific to human samples and has been validated for use in Western blotting applications.KAT6A, also known as MYST3 or MOZ, plays a critical role in various cellular processes including transcriptional regulation, DNA repair, and cell cycle control. Dysregulation of KAT6A has been implicated in cancer development, making it a promising target for anticancer therapies.
The KAT6A Polyclonal Antibody binds specifically to the KAT6A protein, allowing for the detection and analysis of KAT6A expression levels in different cell types.Researchers in the fields of epigenetics, cancer biology, and developmental biology can benefit from using the KAT6A Polyclonal Antibody to explore the functions of KAT6A and its role in disease pathology. By elucidating the molecular mechanisms involving KAT6A, new insights may be gained into potential therapeutic strategies for treating a variety of diseases.
Product Name:
KAT6A Rabbit Polyclonal Antibody
SKU:
CAB15006
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 800-1000 of human KAT6A (NP_001092883.1).
This gene encodes a member of the MOZ, YBFR2, SAS2, TIP60 family of histone acetyltransferases. The protein is composed of a nuclear localization domain, a double C2H2 zinc finger domain that binds to acetylated histone tails, a histone acetyl-transferase domain, a glutamate/aspartate-rich region, and a serine- and methionine-rich transactivation domain. It is part of a complex that acetylates lysine-9 residues in histone 3, and in addition, it acts as a co-activator for several transcription factors. Allelic variants of this gene are associated with an autosomal dominant form of cognitive disability. Chromosomal translocations of this gene are associated with acute myeloid leukemia. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
7994
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from 293T cells, using KAT6A Rabbit pAb (CAB15006) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
