The KAT2A Polyclonal Antibody (CAB2224) is a valuable tool for researchers studying KAT2A, a protein involved in epigenetic regulation and gene expression. This antibody, raised in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By binding to the KAT2A protein, this antibody enables the detection and analysis of KAT2A in various cell types, making it an essential reagent for studies in chromatin remodeling, transcriptional regulation, and cancer research.
KAT2A, also known as GCN5, is a histone acetyltransferase that plays a critical role in modifying chromatin structure and influencing gene expression. Its involvement in epigenetic processes makes it a key target for research into diseases such as cancer, where dysregulation of gene expression can drive tumorigenesis. By understanding the role of KAT2A in gene regulation, researchers can gain insights into potential therapeutic strategies for targeting epigenetic pathways in cancer and other diseases.
Product Name:
KAT2A Rabbit Polyclonal Antibody
SKU:
CAB2224
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-100 of human KAT2A (NP_066564.2).
KAT2A, or GCN5, is a histone acetyltransferase (HAT) that functions primarily as a transcriptional activator. It also functions as a repressor of NF-kappa-B (see MIM 164011) by promoting ubiquitination of the NF-kappa-B subunit RELA (MIM 164014) in a HAT-independent manner (Mao et al., 2009 [PubMed 19339690]).
Purification Method:
Affinity purification
Gene ID:
2648
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of lysates from Rat brain, using KAT2A Rabbit pAb (CAB2224) at 1:400 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
