The KALRN Polyclonal Antibody (PACO10034) is a valuable tool for researchers studying the KALRN protein, a key regulator of cytoskeletal dynamics and cell signaling. This antibody, developed using rabbit immunization, exhibits high specificity and sensitivity in detecting KALRN in human samples, making it a reliable tool for Western blot applications. By binding to the KALRN protein, researchers can investigate its role in cell structure and function in various cell types, offering insights into processes such as cell migration, adhesion, and proliferation.KALRN, also known as kalirin, is a multifunctional protein involved in neuronal development, synaptic plasticity, and cell migration.
Its dysregulation has been implicated in various diseases, including neurological disorders and cancer. By studying the function of KALRN, researchers can gain a better understanding of its role in these conditions and potentially identify new therapeutic targets for intervention. The KALRN Polyclonal Antibody is a valuable tool for advancing research in neuroscience, cancer biology, and other fields where KALRN plays a critical role.
Promotes the exchange of GDP by GTP. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity.
UniProt Protein Details:
NCBI Summary:
Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein that interacts with the huntingtin-associated protein 1, which is a huntingtin binding protein that may function in vesicle trafficking. [provided by RefSeq, Apr 2016]
