The KALRN Polyclonal Antibody (PACO05661) is a reliable tool for researchers studying the KALRN protein, an important regulator of cell morphology and signaling pathways. This antibody, produced in rabbits, exhibits strong reactivity with human samples and is validated for use in Western blot applications. By specifically binding to the KALRN protein, it enables researchers to detect and analyze this protein in a variety of cell types, making it an ideal choice for studies in cell biology and neuroscience.KALRN, also known as kalirin, is a Rho guanine nucleotide exchange factor that plays a critical role in the regulation of actin cytoskeleton dynamics and neuronal development.
Dysregulation of KALRN expression has been associated with neurological disorders such as schizophrenia and Alzheimer's disease, highlighting its importance in the field of neuroscience research. By elucidating the function of KALRN, researchers can gain valuable insights into the mechanisms underlying these diseases and potentially identify new therapeutic targets for treatment.
Antibody Name:
KALRN Antibody (PACO05661)
Antibody SKU:
PACO05661
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:20000, WB:1:500-1:2000
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Synthesized peptide derived from the Internal region of human Duo.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
KALRN; DUET; DUO; HAPIP; TRAD; Kalirin; Huntingtin-associated protein-interacting protein; Protein Duo; Serine/threonine-protein kinase with Dbl- and pleckstrin homology domain
UniProt Protein Function:
Promotes the exchange of GDP by GTP. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity.
UniProt Protein Details:
NCBI Summary:
Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein that interacts with the huntingtin-associated protein 1, which is a huntingtin binding protein that may function in vesicle trafficking. [provided by RefSeq, Apr 2016]
