The Kallikrein-6 Polyclonal Antibody (CAB12055) is a valuable tool for researchers studying Kallikrein-6, a serine protease enzyme associated with various physiological processes and diseases. This antibody, generated from rabbits, is highly specific for detecting Kallikrein-6 in human samples and has been validated for use in Western blot applications.Kallikrein-6, also known as Neurosin, is involved in the proteolytic degradation of proteins and peptides, playing a role in processes such as neurodegeneration, cancer progression, and inflammation. Its expression and activity have been linked to conditions such as Alzheimer's disease, ovarian cancer, and multiple sclerosis, making it a promising target for diagnostic and therapeutic interventions.
By using the Kallikrein-6 Polyclonal Antibody, researchers can accurately detect and quantify Kallikrein-6 levels in various samples, shedding light on its physiological functions and potential implications in disease pathogenesis. This antibody is a valuable tool for advancing research in neuroscience, oncology, and immunology, providing insights that could lead to the development of novel treatments and diagnostic tools.
Product Name:
KLK6 Rabbit Polyclonal Antibody
SKU:
CAB12055
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 100 to the C-terminus of human KLK6 (NP_002765.1).
This gene encodes a member of the kallikrein subfamily of the peptidase S1 family of serine proteases. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. The encoded preproprotein is proteolytically processed to generate the mature protease. Expression of this protease is regulated by steroid hormones and may be elevated in multiple human cancers and in serum from psoriasis patients. The encoded protease may participate in the cleavage of amyloid precursor protein and alpha-synuclein, thus implicating this protease in Alzheimer's and Parkinson's disease, respectively. This gene is located in a gene cluster on chromosome 19. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.
Purification Method:
Affinity purification
Gene ID:
5653
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from HT-29 cells, using KLK6 Rabbit pAb (CAB12055) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 90s.
