The Kallikrein 6 Polyclonal Antibody (CAB11972) is a valuable tool for researchers studying Kallikrein 6, a serine protease involved in various biological processes, including tumor progression and metastasis. This antibody, generated in rabbits, exhibits high specificity and sensitivity for detecting Kallikrein 6 in human samples, making it suitable for use in Western blotting and other immunological techniques.Kallikrein 6, also known as Klk6, is known to play a significant role in cancer development and progression, particularly in ovarian and breast cancer.
Its dysregulation has been linked to poor prognosis and resistance to chemotherapy, highlighting its potential as a therapeutic target. By utilizing the Kallikrein 6 Polyclonal Antibody, researchers can better understand the mechanisms underlying Kallikrein 6 function and its implications in cancer biology, paving the way for the development of novel treatment strategies.
Product Name:
KLK6 Rabbit Polyclonal Antibody
SKU:
CAB11972
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 100 to the C-terminus of human KLK6 (NP_002765.1).
This gene encodes a member of the kallikrein subfamily of the peptidase S1 family of serine proteases. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. The encoded preproprotein is proteolytically processed to generate the mature protease. Expression of this protease is regulated by steroid hormones and may be elevated in multiple human cancers and in serum from psoriasis patients. The encoded protease may participate in the cleavage of amyloid precursor protein and alpha-synuclein, thus implicating this protease in Alzheimer's and Parkinson's disease, respectively. This gene is located in a gene cluster on chromosome 19. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.
Purification Method:
Affinity purification
Gene ID:
5653
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using KLK6 Rabbit pAb (CAB11972) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
