The Kallikrein 5 Polyclonal Antibody (CAB2991) is a valuable tool for researchers studying Kallikrein 5, a serine protease enzyme linked to skin diseases and inflammation. This antibody, derived from rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the Kallikrein 5 protein, this antibody enables accurate detection and analysis in various cell types, making it suitable for investigations in dermatology and immune-related research.
Kallikrein 5, also known as stratum corneum chymotryptic enzyme, is involved in processes such as desquamation and skin barrier function, making it a target of interest in studies on skin disorders like psoriasis and atopic dermatitis. Its role in inflammation regulation suggests potential implications in conditions beyond dermatology, such as cancer and autoimmune diseases. Unraveling the functions of Kallikrein 5 could lead to the development of novel therapeutic strategies for managing these diseases.
Product Name:
KLK5 Rabbit Polyclonal Antibody
SKU:
CAB2991
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 41-177 of human KLK5 (NP_036559.1).
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its expression is up-regulated by estrogens and progestins. The encoded protein is secreted and may be involved in desquamation in the epidermis. Alternative splicing results in multiple transcript variants encoding the same protein.
Purification Method:
Affinity purification
Gene ID:
25818
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using KLK5 antibody (CAB2991) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3s.
